FGF1 Antikörper

Produktnummer ABIN1685162

Produktdetails anti-FGF1 Antikörper

Target: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Polyclonal acidic FGF antibody was produced from sera of rabbits immunized with synthetic protein containing aFGF antigenic determinants.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: Use at a concentration range of 1-2 µg/mL.
Western blot: A suitable range of concentrations of this antibody for WB detection is 10 µg/mL.
IHC: A suitable range of concentrations of this antibody for IHC is 10 µg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers

Buffer: PBS solution at a concentration of 1 mg/mL.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Recombinant CD48, as supplied, can be stored in working aliquots at - 8 °C for one month, or at -20 °C to -70 °C for twelve months.

Haltbarkeit: 12 months

Details zu FGF1

Target: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Andere Bezeichnung: aFGF (FGF1 Produkte)

Synonyme: AFGF antikoerper, ECGF antikoerper, ECGF-beta antikoerper, ECGFA antikoerper, ECGFB antikoerper, FGF-1 antikoerper, FGF-alpha antikoerper, FGFA antikoerper, GLIO703 antikoerper, HBGF-1 antikoerper, HBGF1 antikoerper, Fgf1 antikoerper, FGF1 antikoerper, aFGF antikoerper, ecgf antikoerper, fgfa antikoerper, ecgfa antikoerper, ecgfb antikoerper, fgf-1 antikoerper, hbgf1 antikoerper, glio703 antikoerper, ecgf-beta antikoerper, fgf-alpha antikoerper, Dffrx antikoerper, Fam antikoerper, Fgf-1 antikoerper, Fgfa antikoerper, zgc:136885 antikoerper, LOC100221393 antikoerper, fgf1 antikoerper, zgc:73249 antikoerper, fibroblast growth factor 1 antikoerper, fibroblast growth factor 1 L homeolog antikoerper, fibroblast growth factor 1b antikoerper, fibroblast growth factor 1a antikoerper, FGF1 antikoerper, fgf1.L antikoerper, fgf1 antikoerper, Fgf1 antikoerper, fgf1b antikoerper, LOC100221393 antikoerper, fgf1a antikoerper

Hintergrund: CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for B4. CD48/2B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk. The absence of functional B4/CD48 interactions impairs NK cell cytotoxic response and IFN- release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by aB4/CD48-dependent mechanism.

UniProt: P05230

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung