FLT1 Antikörper (Soluble)
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- Target Alle FLT1 Antikörper anzeigen
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
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Bindungsspezifität
- Soluble
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FLT1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- Peptide: GEHCNKKAVFSRISKFKSTR NDSTTQSNVKH.
- Produktmerkmale
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Chromosomal location: 13q12
Produced from sera of rabbits immunised with a peptide of the C-terminal end of native human soluble VEGFR-1/Flt-1 (CNKKAVFSRISKFKSTRNDSTTQSNVKH). - Aufreinigung
- Anti-human soluble VEGFR-1/Flt-1 was purified by affinity chromatography with immobilized Protein A.
- Isotyp
- IgG
- Top Product
- Discover our top product FLT1 Primärantikörper
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- Applikationshinweise
- Western Blot: use 1-5 µg/mL
- Kommentare
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Rabbit IG Polyclonal Antibody
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS
- Handhabung
- Centrifuge vial prior to opening.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- Haltbarkeit
- 6 months
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- Target
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
- Andere Bezeichnung
- VEGFR-1/Flt-1 (FLT1 Produkte)
- Synonyme
- FLT antikoerper, FLT-1 antikoerper, VEGFR-1 antikoerper, VEGFR1 antikoerper, FLT1 antikoerper, flt1b antikoerper, sFlt1 antikoerper, AI323757 antikoerper, Flt-1 antikoerper, fms related tyrosine kinase 1 antikoerper, FMS-related tyrosine kinase 1 antikoerper, vascular endothelial growth factor receptor 1 antikoerper, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antikoerper, FMS-like tyrosine kinase 1 antikoerper, vascular endothelial growth factor receptor-1 antikoerper, FLT1 antikoerper, Flt1 antikoerper, CpipJ_CPIJ012087 antikoerper, flt1 antikoerper, FLT-1 antikoerper
- Hintergrund
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Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
Synonyms: soluble vascular endothelial growth factor receptor-1, soluble FLT1, soluble FLT, soluble VEGF receptor 1 - NCBI Accession
- NM_001159920, NP_001153392
- UniProt
- P17948
- Pathways
- RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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