ALKBH1 Antikörper (N-Term)

Produktnummer ABIN1449917

Produktdetails anti-ALKBH1 Antikörper

Target: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PGFIFIPNPF LPGYQWHWVK QCLKLYSQKP NVCNLDKHMS KEETQDLWEQ

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Dog, MouseSpecies reactivity (tested):Human

Aufreinigung: Immunoaffinity column

Immunogen: Synthetic peptide corresponding to a N-terminal region of human ALKBH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu ALKBH1

Target: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Andere Bezeichnung: ALKBH1 (ALKBH1 Produkte)

Synonyme: Alkbh antikoerper, ABH antikoerper, ABH1 antikoerper, ALKBH antikoerper, alkB antikoerper, hABH antikoerper, 2700073G19Rik antikoerper, Abh antikoerper, alkB homolog 1, histone H2A dioxygenase antikoerper, Alkbh1 antikoerper, ALKBH1 antikoerper

Hintergrund: ALKBH1 is a dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. This requires molecular oxygen, alpha-ketoglutarate and iron. ALKBH1 may have a role in placental trophoblast lineage differentiation, has DNA lyase activity and introduces double-stranded breaks at abasic sites. It cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.Synonyms: ABH, ALKBH, Alkylated DNA repair protein alkB homolog 1

Molekulargewicht: ALX1: 37 kDa

Gen-ID: 8846

NCBI Accession: NP_006011

Pathways: DNA Reparatur