AKR1C3 Antikörper (AA 161-270) (Cy7)

Produktnummer ABIN1408950

Produktdetails anti-AKR1C3 Antikörper (Cy7)

Target: AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))

Bindungsspezifität: AA 161-270

Reaktivität: Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKR1C3 Antikörper ist konjugiert mit Cy7

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Kaninchen

Homologie: Human,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AKR1C3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu AKR1C3

Target: AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))

Andere Bezeichnung: AKR1C3/DD3 (AKR1C3 Produkte)

Synonyme: AKR1C3 antikoerper, PGFS antikoerper, MGC134333 antikoerper, DD3 antikoerper, DDX antikoerper, HA1753 antikoerper, HAKRB antikoerper, HAKRe antikoerper, HSD17B5 antikoerper, hluPGFS antikoerper, Akr1c18 antikoerper, aldo-keto reductase family 1, member C3 L homeolog antikoerper, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) antikoerper, aldo-keto reductase family 1 member C2 antikoerper, aldo-keto reductase family 1 member C3 antikoerper, aldo-keto reductase family 1, member C3 antikoerper, akr1c3.L antikoerper, AKR1C3 antikoerper, LOC722496 antikoerper, Akr1c3 antikoerper

Hintergrund:

Synonyms: 17 beta HSD 5, 17 beta hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 17-beta-hydroxysteroid dehydrogenase type 5, 2-dihydrobenzene-1, 2-diol dehydrogenase, 3 alpha hydroxysteroid dehydrogenase type II, 3-alpha-HSD type 2, 3-alpha-HSD type II, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, AK1C3_HUMAN, AKR1 C3, AKR1C3, Aldo keto reductase family 1 member C3, Aldo-keto reductase family 1 member C3, brain, Chlordecone reductase, Chlordecone reductase homolog HAKRb, DD-3, DD3, DDH1, DDX, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase type I, Dihydrodiol dehydrogenase X, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, Indanol dehydrogenase, KIAA0119, PGFS, Prostaglandin F synthase, Testosterone 17-beta-dehydrogenase 5, Trans-1, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type IIb 3 alpha hydroxysteroid dehydrogenase.

Background: DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.,Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20Alpha- or 3Alpha-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1 while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3Alpha-HSD are alternate designations for DD3, while DD4 also can be called AKR1C4, CD or CHDR. DD1 and DD2 are 20Alpha-HSDs, whereas DD3 and DD4 are the 3Alpha-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20Alpha-HSD catalyzes the reaction of progesterone to the inactive form 20Alpha-hydroxyprogesterone. The 3Alpha-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver.

Gen-ID: 8644

Pathways: Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Biosynthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, C21-Steroid Hormone Metabolic Process, Protein targeting to Nucleus