DPYSL2 Antikörper (pSer518, pThr514) (Alexa Fluor 647)

Produktnummer ABIN1398204

Produktdetails anti-DPYSL2 Antikörper (Alexa Fluor 647)

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Bindungsspezifität: pSer518, pThr514

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPYSL2 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CRMP2 around the phosphorylation site of Thr514+Ser518

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DPYSL2

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Andere Bezeichnung: CRMP2+ (DPYSL2 Produkte)

Synonyme: CRMP-2 antikoerper, CRMP2 antikoerper, DHPRP2 antikoerper, DRP-2 antikoerper, DRP2 antikoerper, N2A3 antikoerper, ULIP-2 antikoerper, ULIP2 antikoerper, TOAD-64 antikoerper, crmp2 antikoerper, dhprp2 antikoerper, drp-2 antikoerper, drp2 antikoerper, unc-33 antikoerper, unc33 antikoerper, dpysl2 antikoerper, CRMP 2 antikoerper, PCRMP 2 antikoerper, PCRMP-2 antikoerper, PCRMP2 antikoerper, PfCRMP 2 antikoerper, PfCRMP-2 antikoerper, AI851130 antikoerper, Crmp2 antikoerper, Musunc33 antikoerper, Ulip2 antikoerper, CRMP2A antikoerper, dihydropyrimidinase like 2 antikoerper, dihydropyrimidinase-like 2 antikoerper, dihydropyrimidinase like 2 L homeolog antikoerper, dihydropyrimidinase-like 2b antikoerper, cysteine repeat modular protein 2, putative antikoerper, DPYSL2 antikoerper, dpysl2.L antikoerper, dpysl2b antikoerper, PfCRMP2 antikoerper, dpysl2 antikoerper, Dpysl2 antikoerper

Hintergrund:

Synonyms: CRMP2 phospho T514 + S518, CRMP2 phospho T514+S518, CRMP-2phospho Thr514+S518, p-CRMP2Thr514+S518, CRMP2/Dpysl2DRP 2, Collapsin response mediator protein 2, Collapsin response mediator protein hCRMP 2, CRAM, CRMP 2, DHPRP 2, DHPRP2, Dihydr pyrimidinase 2, Dihydropyrimidinase 2, Dihydropyrimidinase like 2, Dihydropyrimidinase like 2 long form,Dihydropyrimidinase related protein 2, DPYL 2, DPYL2, DPYSL 2, DPYSL2, DRP 2, DRP2, Musunc 33, Musunc33, N2A3, TOAD 64, TOAD64, ULIP 2 protein, Ulip2.

Background: Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Gen-ID: 1808

Pathways: Regulation of Cell Size