LMX1B Antikörper (AA 111-210) (Alexa Fluor 555)

Produktnummer ABIN1393277

Produktdetails anti-LMX1B Antikörper (Alexa Fluor 555)

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Bindungsspezifität: AA 111-210

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LMX1B Antikörper ist konjugiert mit Alexa Fluor 555

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LMX1b/NPS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu LMX1B

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Andere Bezeichnung: LMX1b/NPS1 (LMX1B Produkte)

Synonyme: LMX1.2 antikoerper, NPS1 antikoerper, LMX antikoerper, LMX1 antikoerper, LMX1.1 antikoerper, lmx1b antikoerper, lmx1b.1 antikoerper, Xlmx1b antikoerper, lmx1b.2 antikoerper, LIM homeobox transcription factor 1 beta antikoerper, LIM homeobox transcription factor 1, beta b antikoerper, LIM homeobox transcription factor 1, beta, gene 1 S homeolog antikoerper, LIM homeobox transcription factor 1, beta a antikoerper, LMX1B antikoerper, Lmx1b antikoerper, lmx1bb antikoerper, lmx1b.1.S antikoerper, lmx1ba antikoerper

Hintergrund:

Synonyms: LIM homeo box transcription factor 1 beta, LIM homeobox transcription factor 1 beta, LIM homeobox transcription factor 1-beta, LIM-homeobox protein 1.2, LIM/homeobox protein 1.2, LIM/homeobox protein LMX1B, LMX 1.2, LMX-1.2, LMX1.2, LMX1B, LMX1B_HUMAN, NPS 1, NPS1.

Background: Nail-patella syndrome (NPS) is an autosomal dominant disorder characterized by dyplasia of finger nails, skeletal anomalies and, frequently, renal disease. NPS is caused by putative loss-of-function mutations in the transcription factor LMX1B. LMX1B belongs to the LIM-homeodomain family, members of which are known to be important for pattern formation during development. Twenty-two novel mutations may occur in the gene encoding LMX1B and the type and distribution of the mutations support the hypothesis that NPS is the result of haploinsufficiency for LMX1B. LMX1B is also necessary for normal development of the eye and in regulating dopaminergic neurogenesis and may be involved in developmental glaucoma and the aetiology of idiopathic Parkinson?s disease. Specifically, LMX1B along with LIM1 control the initial trajectory of motor axons in the developing mammalian limb. In addition, LMX1B directly regulates the coordinated expression of alpha 3(IV) and alpha 4(IV) collagen required for normal glomerular basement membrane (GBM) morphogenesis, and the dysregulation of LMX1B in GBM contributes to the renal pathology and nephrosis in NPS.

Gen-ID: 4010

UniProt: O60663

Pathways: Dopaminergic Neurogenesis