RPA1 Antikörper (AA 201-300) (AbBy Fluor® 555)
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- Target Alle RPA1 Antikörper anzeigen
- RPA1 (Replication Protein A1, 70kDa (RPA1))
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Bindungsspezifität
- AA 201-300
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RPA1 Antikörper ist konjugiert mit AbBy Fluor® 555
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human
- Homologie
- Mouse,Rat,Dog,Pig,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human RPA70
- Isotyp
- IgG
- Top Product
- Discover our top product RPA1 Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- RPA1 (Replication Protein A1, 70kDa (RPA1))
- Andere Bezeichnung
- RPA70 (RPA1 Produkte)
- Synonyme
- HSSB antikoerper, MST075 antikoerper, REPA1 antikoerper, RF-A antikoerper, RP-A antikoerper, RPA70 antikoerper, Cb1-727 antikoerper, wu:fi14b08 antikoerper, zgc:55337 antikoerper, zgc:77092 antikoerper, RPA1 antikoerper, hssb antikoerper, mst075 antikoerper, repa1 antikoerper, rf-a antikoerper, rp-a antikoerper, rpa antikoerper, rpa70 antikoerper, LOC100230990 antikoerper, 5031405K23Rik antikoerper, 70kDa antikoerper, AA589576 antikoerper, AW557552 antikoerper, Rpa antikoerper, CG9633 antikoerper, D-RPA70 antikoerper, D-SSB antikoerper, DRP-A antikoerper, DmRPA antikoerper, Dmel\\CG9633 antikoerper, RPA antikoerper, RPA 70 antikoerper, RPA 70 kDa antikoerper, RpA70 antikoerper, Rpa-70 antikoerper, Ssb-70 antikoerper, dRP-A antikoerper, dmrpa1 antikoerper, i164 antikoerper, replication protein A1 antikoerper, replication protein A1, 70kDa antikoerper, replication protein A1 L homeolog antikoerper, Replication Protein A 70 antikoerper, RPA1 antikoerper, Rpa1 antikoerper, rpa1 antikoerper, rpa1.L antikoerper, RpA-70 antikoerper
- Hintergrund
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Synonyms: Dmrpa1, Drosophila Replication Protein A, DRPA, HSSB, Human single stranded DNA binding protein, MST075, MSTP075, p70 antibody REPA1, Replication factor A, Replication factor A protein 1, Replication protein A 70 kDa DNA-binding subunit, Replication protein A 70 kDa DNA binding subunit, Replication protein A1 70 kDa, Replication protein A1, RF A, RF-A protein 1, RFA, RFA1_HUMAN, RP A, RP-A p70, RPA 70, RPA, RPA1, Single stranded binding protein 70, Single-stranded DNA-binding protein.
Background: The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB. RPA plays an important role in DNA replication, recombination and repair. The binding of human RPA (hRPA) to DNA involves molecular polarity in which initial hRPA binding occurs on the 5' side of an ssDNA substrate and then extends in the 3' direction to create a stably bound hRPA. RPA is a major damage-recognition protein involved in the early stages of nucleotide excision repair. It can also play a role in telomere maintenance. The RPA 70 kDa subunit binds to ssDNA and mediates interactions with many cellular and viral proteins. The DNA binding domain lies in the middle of RPA 70 kDa subunit and comprises two structurally homologous subdomains oriented in tandem. RPA contains a conserved four cysteine-type zinc-finger motif, which mediates the transition of RPA-ssDNA interaction to a stable RPA-ssDNA complex in a redox-dependent manner.
- Pathways
- Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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