Kv1.4 Antikörper (AA 555-653)

Produktnummer ABIN1387916

Der Kaninchen Polyklonal anti-Kv1.4 Antikörper wird verwendet zum Nachweis von Kv1.4 in Proben von Human. Er wurde validiert für ELISA, ICC, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für Kv1.4 Antikörper (AA 555-653) (ABIN1387916)

Target: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kv1.4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Kv1.4 Antikörper

Bindungsspezifität: AA 555-653

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kv1.4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Kv1.4

Target: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Andere Bezeichnung: Kv1.4

Hintergrund:

Synonyms: Voltage gated K+ channel HuKII, cardiac potassium channel, fetal skeletal muscle potassium channel, HBK 4, HBK4, HK 1, HK1, HPCN 2, HPCN2, HUK II, HUKII, KCNA 4, KCNA 8, KCNA4, KCNA4_HUMAN, KCNA4L, KCNA8, kv1.4, PCN 2, PCN2, potassium channel 2, potassium channel KCNA4, potassium channel protein, Potassium voltage gated channel shaker related subfamily member 4, Potassium voltage gated channel subfamily A member 4, potassium voltage-gated channel shaker-related subfamily member 4-like, Potassium voltage-gated channel subfamily A member 4, rapidly inactivating potassium channel, Shaker related potassium channel Kv1.4, shaker-related potassium channel Kv1.4, type A potassium channel, Voltage gated potassium channel HBK4, Voltage gated potassium channel HK1, Voltage gated potassium channel subunit Kv1.4, Voltage-gated K+ channel HuKII, voltage-gated potassium channel, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, voltage-gated potassium channel protein Kv1.4, Voltage-gated potassium channel subunit Kv1.4.

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.