Kv1.4 Antikörper (C-Term)

Produktnummer ABIN1881472

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Kv1.4 in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für Kv1.4 Antikörper (C-Term) (ABIN1881472)

Target: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kv1.4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41939

Produktdetails anti-Kv1.4 Antikörper

Bindungsspezifität: AA 591-619, C-Term

Homologie: B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Kv1.4 Antikörper (ABIN1881472)

Schwetz, Norring, Bennett: "N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating." in: Biochimica et biophysica acta, Vol. 1798, Issue 3, pp. 367-75, (2010) (PubMed).

Lee, Lee, Choi, Yoon, Pyo, Shin, Choi, Lim, Rhim, Won, Lim, Choe, Kim, Kim, Nah: "Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue." in: Molecular pharmacology, Vol. 73, Issue 3, pp. 619-26, (2008) (PubMed).

Mckeown, Burnham, Hodson, Jones et al.: "Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in..." in: The Journal of biological chemistry, Vol. 283, Issue 44, pp. 30421-32, (2008) (PubMed).

Details zu Kv1.4

Target: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Andere Bezeichnung: KCNA4

Hintergrund: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Molekulargewicht: 73257

NCBI Accession: NP_002224

UniProt: P22459