KCNA1 Antikörper (AA 281-350)

Produktnummer ABIN1387826

Produktdetails anti-KCNA1 Antikörper

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Bindungsspezifität: AA 281-350

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kv1.1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu KCNA1

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Andere Bezeichnung: Kv1.1 (KCNA1 Produkte)

Synonyme: AEMK antikoerper, EA1 antikoerper, HBK1 antikoerper, HUK1 antikoerper, KV1.1 antikoerper, MBK1 antikoerper, MK1 antikoerper, RBK1 antikoerper, KCNA1 antikoerper, AI840627 antikoerper, Kca1-1 antikoerper, Kv1.1 antikoerper, Mk-1 antikoerper, Shak antikoerper, mceph antikoerper, Kcna antikoerper, Kcpvd antikoerper, potassium voltage-gated channel subfamily A member 1 antikoerper, potassium voltage-gated channel, shaker-related subfamily, member 1 antikoerper, fragile site, aphidicolin type, common, fra(12)(q24) antikoerper, KCNA1 antikoerper, Kcna1 antikoerper, FRA12E antikoerper

Hintergrund:

Synonyms: Kv1.1 potassium channel, AEMK, EA1, Episodic ataxia with myokymia, HBK1, HUK1, Kca1 1, Kcna1, KCNA1_HUMAN, Kcpvd, KV1.1, MBK1, mceph, MGC124402, MGC126782, MGC138385, MK1, Potassium channel protein 1, Potassium voltage gated channel shaker related subfamily member 1, Potassium voltage gated channel subfamily A member 1, Potassium voltage-gated channel subfamily A member 1, RBK1, Shak, Shaker related subfamily member 1, Voltage gated potassium channel subunit Kv1.1, Voltage-gated K+ channel HuKI, Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv1.1.

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.