STAT6 Antikörper
-
- Target Alle STAT6 Antikörper anzeigen
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
-
Reaktivität
- Human, Hund
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser STAT6 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody specifically recognizes STAT6 at 100 kDa.
- Produktmerkmale
- Synonyms: STAT-6, IL-4 Stat, IL-4-STAT, Signal transducer and activator of transcription 6
- Aufreinigung
- Size Exclusion Chromatography
- Bestandteile
- incl. positive Control
- Immunogen
- Synthetic peptide conjuagted to KLH
- Klon
- 8C12
- Isotyp
- IgG1
- Top Product
- Discover our top product STAT6 Primärantikörper
-
-
- Applikationshinweise
-
Western Blot: 1 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer. ELISA: 0.05 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Rekonstitution
- Restore with 1 mL H2O (15 min, RT).
- Buffer
- 1 mL2 x PBS / 0.09 % Sodium Azide / PEG and Sucrose
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C/-80 °C
- Informationen zur Lagerung
-
Store lyophilized (preferably in a desiccator) at -20 °C and reconstituted (aliquote andfreeze in liquid nitrogen) at -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months.
Shelf life: one year from despatch. - Haltbarkeit
- 12 months
-
- Target
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- Andere Bezeichnung
- STAT6 (STAT6 Produkte)
- Synonyme
- D12S1644 antikoerper, IL-4-STAT antikoerper, STAT6B antikoerper, STAT6C antikoerper, signal transducer and activator of transcription 6 antikoerper, signal transducer and activator of transcription 6-like antikoerper, STAT6 antikoerper, Stat6 antikoerper, LOC100859543 antikoerper
- Hintergrund
- The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STATs are mediators involved in cytokine signalling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinase (JAK). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it paricipates in transcriptional control.Synonyms: IL-4 Stat, Signal transducer and activator of transcription 6
- Gen-ID
- 6778
- UniProt
- P42226
- Pathways
- JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
-