Myeloperoxidase Antikörper (PE)

Produktnummer ABIN119049

Produktdetails anti-Myeloperoxidase Antikörper (PE)

Target: Myeloperoxidase (MPO)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Myeloperoxidase Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Keine Kreuzreaktivität: Ratte (Rattus)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Human Myeloperoxiase Remarks: Spleen cells from immunised mice were fused with cells of the mouse X63 AG8-653 myeloma cell line.

Klon: 2C7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Membrane permeabilisation is required for this application.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1 mL distilled water

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative, 1 % BSA and 5 % sucrose as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: This product is photosensitive and should be protected from light

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Referenzen für anti-Myeloperoxidase Antikörper (PE) (ABIN119049)

Lau, Mollnau, Eiserich, Freeman, Daiber, Gehling, Brümmer, Rudolph, Münzel, Heitzer, Meinertz, Baldus: "Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 2, pp. 431-6, (2005) (PubMed).

Details zu Myeloperoxidase

Target: Myeloperoxidase (MPO)

Andere Bezeichnung: Myeloperoxidase (MPO Produkte)

Synonyme: mKIAA4033 antikoerper, MPO antikoerper, LOC100335032 antikoerper, POX2' antikoerper, XPOX2' antikoerper, mpo antikoerper, mpo-A antikoerper, pmr-1 antikoerper, pmr1 antikoerper, pox2 antikoerper, xpox2 antikoerper, myeloperoxidase antikoerper, myeloperoxidase L homeolog antikoerper, MPO antikoerper, Mpo antikoerper, LOC100335032 antikoerper, mpo.L antikoerper

Hintergrund: MPO is an important component of azurophilic granules in neutrophils. Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.Synonyms: MPO

Gen-ID: 9606

UniProt: P05164

Pathways: Chromatin Binding