FCGR1A Antikörper

Produktnummer ABIN1176933

Produktdetails anti-FCGR1A Antikörper

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCGR1A Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen: Human rheumatoid synovial fluid cells and fibronectin-purified monocytes

Klon: 10-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-FCGR1A Antikörper (ABIN1176933)

van Vugt, Heijnen, Capel, Park, Ra, Saito, Verbeek, van de Winkel: "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo." in: Blood, Vol. 87, Issue 9, pp. 3593-9, (1996) (PubMed).

Dougherty, Selvendran, Murdoch, Palmer, Hogg: "The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1." in: European journal of immunology, Vol. 17, Issue 10, pp. 1453-9, (1987) (PubMed).

Details zu FCGR1A

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Andere Bezeichnung: CD64 (FCGR1A Produkte)

Synonyme: CD64 antikoerper, CD64A antikoerper, FCRI antikoerper, IGFR1 antikoerper, FcgammaRI antikoerper, Fcgr1 antikoerper, Fcgr1b antikoerper, AI323638 antikoerper, AV092959 antikoerper, IGGHAFC antikoerper, FCGR1A antikoerper, Fc fragment of IgG receptor Ia antikoerper, Fc receptor, IgG, high affinity I antikoerper, FCGR1A antikoerper, Fcgr1a antikoerper, Fcgr1 antikoerper

Hintergrund: The 10.1 monoclonal antibody specifically binds to CD64, a 75 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcgammaRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRgamma homodimer to form the functional high affinity FcgammaRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation.
Synonyms: FCGR1, FcRI, Fc-gamma RI, IgG Fc Receptor I, High affinity IgG FcR1

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process