FCGR1A Antikörper (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64))

Produktnummer ABIN1302463

Produktdetails anti-FCGR1A Antikörper

Target: FCGR1A

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCGR1A Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)

Spezifität: The mouse monoclonal antibody 10.1 recognizes alpha subunit of CD64/FcgammaRI, a 72 kDa single chain type I glycoprotein, that is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes.
HLDA III, WS Code M-250

Kreuzreaktivität (Details): Human, Non-Human Primates

Aufreinigung: Purified by protein-A affinity chromatography

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Rheumatoid synovial fluid cells and fibronectin purified human monocytes

Klon: 10-1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Referenzen für anti-FCGR1A Antikörper (ABIN1302463)

Devaraj, Davis, Simon, Jialal: "CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions." in: American journal of physiology. Heart and circulatory physiology, Vol. 291, Issue 3, pp. H1170-6, (2006) (PubMed).

Devaraj, Du Clos, Jialal: "Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 7, pp. 1359-63, (2005) (PubMed).

Roura-Mir, Wang, Cheng, Matsunaga, Dascher, Peng, Fenton, Kirschning, Moody: "Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 3, pp. 1758-66, (2005) (PubMed).

Beekman, Bakema, van der Linden, Tops, Hinten, van Vugt, van de Winkel, Leusen: "Modulation of FcgammaRI (CD64) ligand binding by blocking peptides of periplakin." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33875-81, (2004) (PubMed).

Brichard, Varis, Latinne, Deneys, de Bruyere, Leveugle, Cornu: "Intracellular cytokine profile of cord and adult blood monocytes." in: Bone marrow transplantation, Vol. 27, Issue 10, pp. 1081-6, (2001) (PubMed).

Sánchez-Torres, García-Romo, Cornejo-Cortés, Rivas-Carvalho, Sánchez-Schmitz: "CD16+ and CD16- human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells." in: International immunology, Vol. 13, Issue 12, pp. 1571-81, (2001) (PubMed).

Hashimoto, Yamada, Motoyoshi, Akagawa: "Enhancement of macrophage colony-stimulating factor-induced growth and differentiation of human monocytes by interleukin-10." in: Blood, Vol. 89, Issue 1, pp. 315-21, (1997) (PubMed).

Jayaram, Buckle, Hogg: "The Fc receptor, FcRI, and other activation molecules on human mononuclear phagocytes after treatment with interferon-gamma." in: Clinical and experimental immunology, Vol. 75, Issue 3, pp. 414-20, (1989) (PubMed).

Dougherty, Selvendran, Murdoch, Palmer, Hogg: "The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1." in: European journal of immunology, Vol. 17, Issue 10, pp. 1453-9, (1987) (PubMed).

Details zu FCGR1A

Target: FCGR1A

Andere Bezeichnung: CD64 (FCGR1A Produkte)

Synonyme: CD64, CD64A, FCRI, IGFR1, FcgammaRI, Fcgr1, Fcgr1b, AI323638, AV092959, IGGHAFC, FCGR1A, Fc fragment of IgG receptor Ia, Fc receptor, IgG, high affinity I, FCGR1A, Fcgr1a, Fcgr1

Hintergrund: CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process