Phospholamban Antikörper (N-Term)

Produktnummer ABIN1109616

Produktdetails anti-Phospholamban Antikörper

Target: Phospholamban (PLN)

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects Phospholamban (N-term). No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, rat, mouse.

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human Phospholamban .Remarks: Sequence is identical to the related rat and mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: Phospholamban (PLN Produkte)

Synonyme: LOC100226261 antikoerper, plb antikoerper, cmd1p antikoerper, CMD1P antikoerper, CMH18 antikoerper, PLB antikoerper, Plb antikoerper, Plm antikoerper, phospholamban antikoerper, PLN antikoerper, pln antikoerper, Pln antikoerper

Hintergrund: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.Synonyms: Cardiac phospholamban, PLB, PLN

Gen-ID: 5350

NCBI Accession: NP_002658

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity