PSMC3 Antikörper (Middle Region)

Produktnummer ABIN1108775

Produktdetails anti-PSMC3 Antikörper

Target: PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Xenopus laevis, Hund, Zebrafisch (Danio rerio), Rind (Kuh), Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequenz: TKRFDSEKAG DREVQRTMLE LLNQLDGFQP NTQVKVIAAT NRVDILD

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Dog, Rat, Chicken, Bovine, Zebrafish, African clawed frogSpecies reactivity (tested):Human

Aufreinigung: Purified using Protein A affinity column.

Immunogen: The immunogen for anti-PSMC3 antibody: synthetic peptide directed towards the middle region of human PSMC3.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu PSMC3

Target: PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))

Andere Bezeichnung: PSMC3 / TBP1 (PSMC3 Produkte)

Synonyme: TBP1 antikoerper, TBP-1 antikoerper, wu:fb39a02 antikoerper, zgc:86713 antikoerper, psmc3 antikoerper, MGC89608 antikoerper, PSMC3 antikoerper, NV15940 antikoerper, 23.m06430 antikoerper, DDBDRAFT_0186002 antikoerper, DDBDRAFT_0232967 antikoerper, DDB_0186002 antikoerper, DDB_0232967 antikoerper, psmc3-b antikoerper, tbp10 antikoerper, psmc3-a antikoerper, proteasome 26S subunit, ATPase 3 antikoerper, proteasome (prosome, macropain) 26S subunit, ATPase 3 antikoerper, 26S protease regulatory subunit 6A antikoerper, 26S protease regulatory subunit 6a antikoerper, 26S protease regulatory subunit 6A-B antikoerper, 26S protease regulatory subunit 6A, putative antikoerper, proteasome 26S subunit, ATPase 3 S homeolog antikoerper, nth-like DNA glycosylase 1 S homeolog antikoerper, PSMC3 antikoerper, Psmc3 antikoerper, HCAG_00069 antikoerper, GL50803_4365 antikoerper, EDI_316920 antikoerper, CpipJ_CPIJ006888 antikoerper, CpipJ_CPIJ006889 antikoerper, CpipJ_CPIJ010864 antikoerper, prs6a antikoerper, psmc3 antikoerper, LOC100115023 antikoerper, BBOV_IV004580 antikoerper, CGB_M2140W antikoerper, psmC3 antikoerper, LOC100637883 antikoerper, psmc3.S antikoerper, nthl1.S antikoerper

Hintergrund: PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.Synonyms: 26S protease regulatory subunit 6A, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, TBP-1, Tat-binding protein 1

Gen-ID: 5702

NCBI Accession: NP_002795

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway