Lamin A/C Antikörper (C-Term)

Produktnummer ABIN1108014

Produktdetails anti-Lamin A/C Antikörper

Target: Lamin A/C (LMNA)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin A/C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects Lamin-A/C (LMNA) at C-term. No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human Lamin A/C .Remarks: Sequence is identical to the related rat and mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: Lamin-A/C (LMNA) (LMNA Produkte)

Synonyme: CDCD1 antikoerper, CDDC antikoerper, CMD1A antikoerper, CMT2B1 antikoerper, EMD2 antikoerper, FPL antikoerper, FPLD antikoerper, FPLD2 antikoerper, HGPS antikoerper, IDC antikoerper, LDP1 antikoerper, LFP antikoerper, LGMD1B antikoerper, LMN1 antikoerper, LMNC antikoerper, LMNL1 antikoerper, PRO1 antikoerper, Dhe antikoerper, 2459 antikoerper, 74/76 antikoerper, CG6944 antikoerper, D5 antikoerper, DM[[O]] antikoerper, Dm antikoerper, Dm(0) antikoerper, Dm0 antikoerper, Dm1 antikoerper, Dm2 antikoerper, DmLamin antikoerper, DmO antikoerper, Dm[[0]] antikoerper, Dm[[1]] antikoerper, Dm[[2]] antikoerper, Dm[[mit]] antikoerper, Dm[[o]] antikoerper, Dmel\\CG6944 antikoerper, Dmo antikoerper, LAM antikoerper, Lam Dm[[0]] antikoerper, Lam(Dm0) antikoerper, LamDm[[0]] antikoerper, LamDm[[o]] antikoerper, Lam[[Dm0]] antikoerper, Lamin Dm[[0]] antikoerper, jf27 antikoerper, l(2)04643 antikoerper, l(2)25Ec antikoerper, l(2)gdh-7 antikoerper, l(2)gdh7 antikoerper, l(2)jf27 antikoerper, lam antikoerper, lamDm0 antikoerper, lamDm[[0]] antikoerper, lamin antikoerper, lamin Dm0 antikoerper, lamin Dm[[0]] antikoerper, misg antikoerper, nlam antikoerper, cb948 antikoerper, fk66d12 antikoerper, wu:fk66d12 antikoerper, lmna-A antikoerper, fpl antikoerper, idc antikoerper, lfp antikoerper, cddc antikoerper, emd2 antikoerper, fpld antikoerper, hgps antikoerper, ldp1 antikoerper, lmn1 antikoerper, lmnc antikoerper, pro1 antikoerper, cdcd1 antikoerper, cmd1a antikoerper, cmt2b1 antikoerper, lgmd1b antikoerper, Lamin-A antikoerper, lamin-L(III)-like antikoerper, lamin A/C antikoerper, lamin A antikoerper, Lamin antikoerper, lamin A/C L homeolog antikoerper, lamin-L(III)-like antikoerper, LMNA antikoerper, Lmna antikoerper, Lam antikoerper, lmna antikoerper, lmna.L antikoerper, LMINA antikoerper

Hintergrund: Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C.The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

Gen-ID: 4000

NCBI Accession: NP_005563

UniProt: P02545

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus