Interferon gamma Antikörper (APC)

Produktnummer ABIN1107655

Produktdetails anti-Interferon gamma Antikörper (APC)

Target: Interferon gamma (IFNG)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Interferon gamma Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Spezifität: The antibody detects human IFN-gamma, a 20-25 kDa glycoprotein expressed by subsets of T cells and NK cells, that have been stimulated by antigens or mitogens (1-4). Other species not tested.

Aufreinigung: Affinity chromatography

Klon: 45-14

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Details zu Interferon gamma

Target: Interferon gamma (IFNG)

Andere Bezeichnung: IFNG / Interferon gamma (IFNG Produkte)

Synonyme: IFG antikoerper, IFI antikoerper, IFN-g antikoerper, Ifg antikoerper, IFNG2 antikoerper, IFN-gamma antikoerper, IFN-G antikoerper, IFNG antikoerper, IFNgamma antikoerper, TCRalpha antikoerper, INF-G antikoerper, ifng antikoerper, interferon gamma antikoerper, interferon, gamma 1-2 antikoerper, IFNG antikoerper, Ifng antikoerper, ifng1-2 antikoerper

Hintergrund: The immune system reacts to a pathogen by activation of balanced network of the humoral and cellular immune responses. Subsequently the activated condition of the immune system will, after the elimination of the pathogen, be down-regulated to a balanced situation again. Control of the immune response requires efficient communication between the different cells involved in this response. This interaction is provided by cell/cell contact and by a complex array of mediators. Among these mediators cytokines, soluble factors produced by these cells, play an important role. Cytokines can act on other cells locally or distantly, but can be even auto regulating. Cytokines can behave stimulatory or inhibitory, or can even perform both activities, depending on the (pre)activation stage of the target cell. (3, 4) IFN-gamma has antiviral activity and multiple immunoregulatory functions such as upregulation of MHCClass I antigens on monocytes/macrophages and specific adhesion molecules (e.g. ICAM1 and VCAM1) on endothelial cells. IFN-gamma enhances IgG production by activated B cells, displays chemotactic activities, and plays a role in induction of inflammation.Synonyms: IFN-gamma, gamma IFN

Gen-ID: 3458

NCBI Accession: NP_000610

UniProt: P01579

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie