Desmoplakin Antikörper (Internal Region)

Produktnummer ABIN1106985

Produktdetails anti-Desmoplakin Antikörper

Target: Desmoplakin (DSP)

Bindungsspezifität: AA 1672-1684, Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Desmoplakin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: C-QESVKQAHLR NEH Remarks: Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Marmoset (100%), Monkey (92%), Mouse (92%), Rat (92%), Hamster (92%), Elephant (92%), Dog (92%), Horse (92%), Rabbit (92%), Opossum (92%), Platypus (92%), Panda (85%), Bat (85%), Turkey (85%), Chicken (85%).

Spezifität: This antibody is expected to recognize reported isoform I (NP_004406.2) only.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from the internal region of Human DSP / Desmoplakin (NP_004406.2). Genename: DSP

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Desmoplakin

Target: Desmoplakin (DSP)

Andere Bezeichnung: Desmoplakin (DSP Produkte)

Synonyme: DP antikoerper, DPI antikoerper, DPII antikoerper, DSP antikoerper, dpi antikoerper, dpii antikoerper, 2300002E22Rik antikoerper, 5730453H04Rik antikoerper, AA407887 antikoerper, AA407888 antikoerper, AW109828 antikoerper, im:6911953 antikoerper, sb:cb570 antikoerper, wu:fc17a08 antikoerper, wu:fk73d01 antikoerper, desmoplakin antikoerper, Desmoplakin antikoerper, ORF113 antikoerper, desmoplakin a antikoerper, ORF112 DESMOPLAKIN antikoerper, orf102 antikoerper, orf91; similar to Cydia pomonella granulovirus orf112 antikoerper, ORF62 antikoerper, ORF-66 antikoerper, ORF57 antikoerper, agip105 antikoerper, similar to XcORF133; similar to HaGV desmoplakin antikoerper, desmoplakin L homeolog antikoerper, ORF96 antikoerper, DSP antikoerper, PhopGV104 antikoerper, ORF-59 desmoplakin antikoerper, desmop antikoerper, Dsp antikoerper, dsp antikoerper, desmoplakin antikoerper, dspa antikoerper, orf112 desmoplakin antikoerper, ClgVgp102 antikoerper, COGV_gp091 antikoerper, APNV_p087 antikoerper, CBNV_gp066 antikoerper, EONV_gp057 antikoerper, OLNV_gp066 antikoerper, AgipMNPV_gp105 antikoerper, HaMNV_gp106 antikoerper, EupsNPV_gp065 antikoerper, PsunGV_gp139 antikoerper, dsp.L antikoerper, ClanGV_gp096 antikoerper

Hintergrund: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP

Gen-ID: 1832

NCBI Accession: NP_001008844

Pathways: Cell-Cell Junction Organization