Desmoplakin Antikörper

Produktnummer ABIN7237973

Produktdetails anti-Desmoplakin Antikörper

Target: Desmoplakin (DSP)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmoplakin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human DSP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Desmoplakin

Target: Desmoplakin (DSP)

Andere Bezeichnung: DSP (DSP Produkte)

Synonyme: DP antikoerper, DPI antikoerper, DPII antikoerper, DSP antikoerper, dpi antikoerper, dpii antikoerper, 2300002E22Rik antikoerper, 5730453H04Rik antikoerper, AA407887 antikoerper, AA407888 antikoerper, AW109828 antikoerper, im:6911953 antikoerper, sb:cb570 antikoerper, wu:fc17a08 antikoerper, wu:fk73d01 antikoerper, desmoplakin antikoerper, Desmoplakin antikoerper, ORF113 antikoerper, desmoplakin a antikoerper, ORF112 DESMOPLAKIN antikoerper, orf102 antikoerper, orf91; similar to Cydia pomonella granulovirus orf112 antikoerper, ORF62 antikoerper, ORF-66 antikoerper, ORF57 antikoerper, agip105 antikoerper, similar to XcORF133; similar to HaGV desmoplakin antikoerper, desmoplakin L homeolog antikoerper, ORF96 antikoerper, DSP antikoerper, PhopGV104 antikoerper, ORF-59 desmoplakin antikoerper, desmop antikoerper, Dsp antikoerper, dsp antikoerper, desmoplakin antikoerper, dspa antikoerper, orf112 desmoplakin antikoerper, ClgVgp102 antikoerper, COGV_gp091 antikoerper, APNV_p087 antikoerper, CBNV_gp066 antikoerper, EONV_gp057 antikoerper, OLNV_gp066 antikoerper, AgipMNPV_gp105 antikoerper, HaMNV_gp106 antikoerper, EupsNPV_gp065 antikoerper, PsunGV_gp139 antikoerper, dsp.L antikoerper, ClanGV_gp096 antikoerper

Hintergrund: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

NCBI Accession: NP_004406

UniProt: P15924

Pathways: Cell-Cell Junction Organization