PTPRJ Antikörper (N-Term)

Produktnummer ABIN1105887

Produktdetails anti-PTPRJ Antikörper

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Bindungsspezifität: AA 1-444, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PTPRJ Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein-A affinity chromatography

Reinheit: > 95 % pure by SDS-PAGE

Immunogen: Human recombinant CD148 (amino acids 1-444)

Klon: MEM-CD148-05

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), approx. pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PTPRJ

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Andere Bezeichnung: CD148 / PTPRJ (PTPRJ Produkte)

Synonyme: HAAP antikoerper, CD148 antikoerper, DEP1 antikoerper, HPTPeta antikoerper, R-PTP-ETA antikoerper, SCC1 antikoerper, AI450271 antikoerper, BET antikoerper, Byp antikoerper, DEP-1 antikoerper, PTPbeta2 antikoerper, Ptpb2 antikoerper, RPTPJ antikoerper, Scc-1 antikoerper, Scc1 antikoerper, PTPRJ antikoerper, acid phosphatase 1 antikoerper, protein tyrosine phosphatase, receptor type J antikoerper, protein tyrosine phosphatase, receptor type, J antikoerper, ACP1 antikoerper, PTPRJ antikoerper, Ptprj antikoerper, EUBREC_2762 antikoerper

Hintergrund: CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.Synonyms: DEP-1, DEP1, HPTP eta, Protein-tyrosine phosphatase eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J, R-PTP-eta, Receptor-type tyrosine-protein phosphatase eta

Gen-ID: 5795

NCBI Accession: NP_002834

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling