CBLL1 Antikörper

Produktnummer ABIN1105708

Produktdetails anti-CBLL1 Antikörper

Target: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody reacts with human Hakai, a c-Cbl-like protein.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu CBLL1

Target: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Andere Bezeichnung: CBLL1 / RNF188 (CBLL1 Produkte)

Synonyme: HAKAI antikoerper, RNF188 antikoerper, zgc:55308 antikoerper, CBLL1 antikoerper, AI467391 antikoerper, Hakai antikoerper, c-Cbl-like antikoerper, cbll1 antikoerper, hakai antikoerper, rnf188 antikoerper, Cbl proto-oncogene like 1 antikoerper, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog antikoerper, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase antikoerper, Casitas B-lineage lymphoma-like 1 antikoerper, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog antikoerper, CBLL1 antikoerper, cbll1.S antikoerper, Cbll1 antikoerper, cbll1 antikoerper, cbll1.L antikoerper

Hintergrund: Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.Synonyms: Casitas B-lineage lymphoma-transforming sequence-like protein 1, E3 ubiquitin-protein ligase Hakai, HAKAI, RING finger protein 188, c-Cbl-like protein 1

Gen-ID: 79872

NCBI Accession: NP_079090

UniProt: Q75N03