C3AR1 Antikörper

Produktnummer ABIN1105615

Produktdetails anti-C3AR1 Antikörper

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C3AR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody reacts with the receptor for C3a. It does not block binding of ligand to C3aR.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Klon: 17

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu C3AR1

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Abstract: C3AR1 Produkte

Synonyme: C3AR antikoerper, C3a-R antikoerper, c3ar1 antikoerper, AZ3B antikoerper, HNFAG09 antikoerper, C3a anaphylatoxin chemotactic receptor antikoerper, complement C3a receptor 1 antikoerper, complement component 3a receptor 1 antikoerper, c3ar1 antikoerper, C3AR1 antikoerper, C3ar1 antikoerper

Hintergrund: In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.Synonyms: AZ3B, C3AR, C3AR1, C3R1, C3a anaphylatoxin chemotactic receptor, C3a-R, HNFAG09

Gen-ID: 719

NCBI Accession: NP_004045

UniProt: Q16581

Pathways: Komplementsystem