ACD Antikörper (Middle Region)

Produktnummer ABIN1105207

Produktdetails anti-ACD Antikörper

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KNRPPFPRTG ATRGAQEPCS VWEPPKRHRD GSAFQYEYEP PCTSLCARVQ

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Dog, Horse, Guinea PigSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the middle region of human ACD

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu ACD

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Andere Bezeichnung: ACD (ACD Produkte)

Synonyme: PIP1 antikoerper, PTOP antikoerper, TINT1 antikoerper, TPP1 antikoerper, ACD antikoerper, ACD, shelterin complex subunit and telomerase recruitment factor antikoerper, adrenocortical dysplasia antikoerper, ACD antikoerper, Acd antikoerper

Hintergrund: Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.Synonyms: Adrenocortical dysplasia protein homolog, PIP1, PTOP, TINT1, TPP1

Gen-ID: 65057

NCBI Accession: NP_001075955

Pathways: Telomere Maintenance