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Human HNF4A Protein expressed in HEK-293 Cells - ABIN2722902
Ning, Koh, Pan, Jeong: Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice. in Biochemical pharmacology 2015
Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 (zeige SIRT1 Proteine) mutants, and protein levels for dHNF4 are reduced in sir2 (zeige SIRT1 Proteine) mutant animals. Sir2 (zeige SIRT1 Proteine) exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.
Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.
In summary, HNF4alpha isoforms perform non-redundant functions in the colon under conditions of stress, underscoring the importance of tracking them both in colitis and colon cancer.
Hnf4alpha silencing with shRNA transfection into auditory neuroblast cells (VOT-33) reduced cell viability
both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR (zeige MLXIP Proteine)-122.
Tg737 (zeige IFT88 Proteine) regulates a Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)/Snail (zeige SNAI1 Proteine)-HNF4alpha negative feedback circuit, thereby blocking EMT (zeige ITK Proteine) and the malignant transformation of liver stem cells to liver cancer stem cells.
Down regulation of HNF4 alpha plays a role in metabolic liver function and the pathogenesis of liver cancer.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 (zeige CDX2 Proteine) and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 (zeige CDX2 Proteine) and HNF4alpha in human biopsy samples.
Fibrotic levels of matrix stiffness significantly inhibit hepatocyte-specific functions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-associated protein kinase pathway.
key role in controlling hepatic CES2 expression in diabetes, obesity, or nonalcoholic steatohepatitis
These findings reveal a novel HNF4alpha network controlled by miR (zeige MLXIP Proteine)-194/192 that may play a critical role in maintaining the hepatocyte-differentiated state by inhibiting expression of genes involved in dedifferentiation and tumorigenesis.
HNF4alpha regulates homeostatic proliferation in the gastric epithelium and is both necessary and sufficient for the upstream regulation of the Xbp1-->Mist1 axis in maintenance of zymogen cell secretory architecture.
Analysis of differential gene expression between mesenchymal and epithelial cancer cell lines revealed that hepatocyte nuclear factor 4alpha (HNF4alpha), a transcriptional activator of intestinal (epithelial) differentiation, and its target genes are highly expressed in epithelial cancer cell lines
data suggest that the ERK1/2 pathway plays an important role in the regulation of HNF4alpha-dependent hepatic gene expression.
HNF4alpha upregulated the expression of liver glutaminase 2 (zeige GLS2 Proteine) in HepG2 cells
The Mexican genome-wide association study signal for high serum triglycerides on chromosome 18q11.2 harbors a regulatory single-nucleotide polymorphism, rs17259126, which disrupts normal hepatocyte nuclear factor 4 alpha binding and decreases the expression of the regional TMEM241 gene. Our data suggest that decreased transcript levels of TMEM241 contribute to increased triglyceride levels in Mexicans.
The HNF4alpha-knockdown-induced stimulation of hepcidin could be entirely blocked when BMPR1A was interfered with at the same time.
Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4a has been reported.
Data redefine p.R114W as a pathogenic mutation that causes a distinct clinical subtype of HNF4A MODY with reduced penetrance, reduced sensitivity to sulfonylurea treatment, and no effect on birth weight.
Renal Fanconi syndrome represents the only HNF4A feature showing complete penetrance. Our cases suggest that the p.R63W HNF4A mutation must be considered in subjects with a normal birth weight and postulate the possibility of liver involvement as a part of this condition.
HNF4 positively regulates pUPII gene promoter activity.
Tetra-primer ARMS-PCR identifies the novel genetic variations of bovine HNF-4alpha gene associating with growth traits.
Results show that chicken ovalbumin upstream promoter transcription factor (zeige NR2F1 Proteine) II (COUP-TFII (zeige NR2F2 Proteine)), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor (zeige GHR Proteine) 1A promoter activity through binding to a common DNA element
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
hepatocyte nuclear factor 4 alpha
, hepatocyte nuclear factor 4, alpha
, hepatocyte nuclear factor 4-alpha-like
, hepatocyte nuclear factor 4-alpha
, hepatocyte nuclear factor 4
, hepatocyte nuclear factor 4 homologue
, HNF4 alpha
, Nuclear receptor 2A1
, nuclear receptor subfamily 2 group A member 1
, transcription factor 14
, transcription factor HNF-4
, alpha transcription factor 4
, hepatic nuclear factor 4, alpha
, hepatic nuclear factor 4 alpha
, hepatic nuclear factor 4
, hepatic nuclear factor 4alpha
, nuclear receptor