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Human HSPD1 Protein expressed in Escherichia coli (E. coli) - ABIN1686673
Bukau, Horwich: The Hsp70 and Hsp60 chaperone machines. in Cell 1998
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Bacteria HSPD1 Protein expressed in Escherichia coli (E. coli) - ABIN1686691
Koll, Guiard, Rassow, Ostermann, Horwich, Neupert, Hartl: Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. in Cell 1992
Show all 5 Pubmed References
Human HSPD1 Protein expressed in Escherichia coli (E. coli) - ABIN2004223
Rasmussen, Ji, Eddes, Moritz, Reid, Simpson, Dorow: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2. in Electrophoresis 1997
Show all 5 Pubmed References
The mechanism involved in the interaction of HSP60-Ass conjugate with HLA-DR-DRB allele considering the fact that Ass (1-42) is highly immunogenic in human and interactions evoked highly robust T-cell response through MHC class II binding predictions.
HSP60 showed pro-inflammatory properties in bronchial epithelial cells mediated by activation of TLR-4 (zeige TLR4 Proteine)-related molecules.
HSP60 silencing deactivates the mTOR (zeige FRAP1 Proteine) pathway to suppress glioblastoma progression
the effect of Hsp60 on differentiation and invasion of hepatocellular carcinoma cells might be associated with mitochondrial biogenesis
The results demonstrate that HSP60 participates in mitochondrial progesterone synthesis. These findings provide novel insights into progesterone synthesis in the human placenta and its role in maintaining pregnancy.
Clinical data showed that upregulation of miR (zeige MLXIP Proteine)-382/3-NT and downregulation of HSPD1/Trx (zeige VAC14 Proteine) were also observed in IgA nephropathy patients with renal interstitial fibrosis. These data supported a novel mechanism in which miR (zeige MLXIP Proteine)-382 targets HSPD1 and contributes to the redox imbalance in the development of renal fibrosis.
Low HSP60 expression is associated with beta-cell hypertrophy and dysfunction.
high level of ROS (zeige ROS1 Proteine) is needed for tumorigenesis and progression in tumors with low HSP60 expression
HSP60 regulation of SOX9 (zeige SOX9 Proteine) ubiquitination mitigates the development of knee osteoarthritis.
These findings shed some light on how a tumor cell may avert apoptosis using Hsp60 and point to the anti-cancer potential of drugs, such as CubipyOXA, which interfere with Hsp60/pC3 (zeige PCSK1 Proteine) complex formation, and thus allow the apoptotic cascade to proceed.
Wild type HSP60 displayed a heptameric single-ring structure in the absence of ATP. In contrast, HSP60 formed mainly a "football-type" complex with HSP10 (zeige HSPE1 Proteine) in the presence of ATP and mediated the refolding of denatured substrate protein.
These results indicate that different tissues had different sensitivities to transport stress, possibly resulting in varying levels of cytoprotection by Hsp60 in the different tissues.
This paper reports the localization of both GRP78 (zeige HSPA5 Proteine) and HSP60 on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 in the sperm midpiece.
The ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously for potential vaccine against atherosclerosis. ApoE-/- mice with oral HSP60 administration group showed a significant reduction in plaque size at the aortic root; accompanied by increased Myeloid derived suppressor cells (CD11b+Gr1+) in peripheral blood and spleen.
Overexpressing hsp60 in cultured myoblasts induced only the expression of PGC1 1alpha, suggesting a correlation between Hsp60 overexpression and PGC1 1 alpha activation.
neonatal heart failure through HSP60 induction likely involves developmental defects and excessive apoptosis
Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 (zeige TLR4 Proteine) and ERK MAPK (zeige MAPK1 Proteine) activation
TLR4 (zeige TLR4 Proteine) mediates HSP60-associated apoptosis and that HSP60 has an important role in cardiac myocyte injury, both apoptotic and necrotic.
a direct toxic effect of heat shock protein 60 towards neurons and oligodendrocytes in the CNS involving Toll (zeige TLR4 Proteine)-like receptor4 and MyD88 (zeige MYD88 Proteine) pathways
Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, activated AMPKalpha2 (zeige PRKAA2 Proteine), potentiated mitophagy and mitochondrial biogenesis and enhanced lipid oxidation and secretion in the liver of mice.
It is concluded that nasal administration of HSP60 can inhibit atherosclerotic formation through immune tolerance which is established by Tregs depending on the induction of anti-inflammatory cytokine TGF-beta (zeige TGFB1 Proteine).
Expression of HSP60A is post-transcriptionally regulated in a highly dynamic pattern during embryogenesis, even under heat-shock conditions. In contrast, in very stressful situations, its expression is upregulated transcriptionally over the entire embryo.
Heat-shock protein 60 is required for blastema formation and maintenance during regeneration.
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
60 kDa chaperonin
, 60 kDa heat shock protein, mitochondrial
, P60 lymphocyte protein
, chaperonin 60
, heat shock protein 65
, mitochondrial matrix protein P1
, short heat shock protein 60 Hsp60s1
, heat shock 60 kDa protein 1
, mitochondrial heat shock 60 kDa protein 1
, heat shock protein 60
, heat shock 60kDa protein 1 (chaperonin)
, 60 kDa heat shock protein, mitochondrial-like
, heat shock protein, 60 kDa
, 60-kDa heat shock protein, mitochondrial
, Hsp 60
, heat shock protein 60 kDa
, no blastema
, chaperonin GroEL
, mitochondrial chaperonin
, heat shock 60kD protein 1 (chaperonin)
, heat shock 60kDa protein 1
, heat shock protein 60 (liver)
, LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial