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The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Zusätzlich bieten wir Ihnen ATRX Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ATRX Primary Antibody für IHC, IHC (p) - ABIN4282398
Heaphy, de Wilde, Jiao, Klein, Edil, Shi, Bettegowda, Rodriguez, Eberhart, Hebbar, Offerhaus, McLendon, Rasheed, He, Yan, Bigner, Oba-Shinjo, Marie, Riggins, Kinzler, Vogelstein, Hruban, Maitra et al.: Altered telomeres in tumors with ATRX and DAXX mutations. ... in Science (New York, N.Y.) 2011
Show all 16 Pubmed References
Human Polyclonal ATRX Primary Antibody für ICC, IF - ABIN442805
Wille, Maurer, Piatti, Whittle, Rieder, Singewald, Lusser: Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. in Frontiers in behavioral neuroscience 2015
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Both primary Alternative lengthening of telomeres(ALT) -positive and ATRX/DAXX (zeige DAXX Antikörper)-negative PanNETs are independently associated with aggressive clinicopathologic behavior and displayed reduced recurrence-free survival. In contrast, ALT activation and loss of ATRX/DAXX (zeige DAXX Antikörper) are both associated with better overall survival in patients with metastases
Whole-exome sequencing has identified recurrent mutations in the genes DAXX (zeige DAXX Antikörper) and ATRX, which correlate with loss of protein expression and alternative lengthening of telomeres (ALT).ALT and DAXX (zeige DAXX Antikörper)/ATRX loss in PanNETs was associated with shorter disease-free survival (DFS (zeige FST Antikörper)) and disease-specific survival (DSS (zeige NR0B1 Antikörper)) and likely plays a significant role in driving metastatic disease
The results of this study support an important role for ATRX loss and acquisition of ALT in the biology of NF1 (zeige NF1 Antikörper)-associated gliomas, particularly diffuse and high-grade tumors developing in adults.
We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX (zeige DAXX Antikörper)) prime alternative lengthening of telomeres activation by disrupting telomeric heterochromatin.
Structural and biochemical characterization of DAXX (zeige DAXX Antikörper)-ATRX interaction.
Structural basis for DAXX (zeige DAXX Antikörper) interaction with ATRX.
Review of research progress of TERT (zeige TERT Antikörper)-mediated and ATRX-mediated telomere maintenance and neuroblastoma (zeige ARHGEF16 Antikörper), especially high-risk tumors
This study demonstrated the ATRX loss in glioneuronal tumors with neuropil-like islands.
6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (zeige IDH1 Antikörper)/IDH2 (zeige IDH2 Antikörper), ATRX, and 1p/19q results.
The chromatin remodeling enzyme ATRX is a regulator of therapy induced senescence and drives cells into this state via multiple mechanisms.
Gene expression changes in the Atrx-null retina indicate defective synaptic structure and neuronal circuitry, suggest excitotoxic mechanisms of neurodegeneration, and demonstrate that common targets of ATRX in the forebrain and retina may contribute to similar neuropathological processes underlying cognitive impairment and visual dysfunction in ATR-X syndrome.
mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory.
The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (zeige PARP1 Antikörper) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.
Our study highlights the importance of the cooperation between Rad54 (zeige RAD54L Antikörper) and Mus81 (zeige MUS81 Antikörper) for mediating DNA DSB repair and restraining chromosome missegregation.
The long noncoding RNA, TERRA (zeige DMRT2 Antikörper) can bind both in cis (zeige CISH Antikörper) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (zeige DMRT2 Antikörper) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (zeige DMRT2 Antikörper) activates, ATRX represses gene expression.
The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.
ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.
Daxx (zeige DAXX Antikörper) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (zeige HELLS Antikörper) levels are low.
A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.
We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
ATP-dependent helicase ATRX
, DNA dependent ATPase and helicase
, X-linked helicase II
, X-linked nuclear protein
, Zinc finger helicase
, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
, helicase 2, X-linked
, transcriptional regulator ATRX
, alpha thalassemia/mental retardation syndrome X-linked homolog
, helicase II
, HP1 alpha-interacting protein
, alpha thalassemia/mental retardation syndrome (X-linked)
, heterochromatin protein 2
, DNA repair and recombination protein RAD54-like
, RAD54 homolog