anti-helicase 2, X-linked (ATRX) Antikörper

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Zusätzlich bieten wir Ihnen ATRX Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ATRX 546 P46100
ATRX 22589 Q61687
ATRX 246284  
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Top anti-ATRX Antikörper auf antikoerper-online.de

Showing 10 out of 127 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: ATRX Antibody [NBP1-32851] - Human lung carcinoma dilution: 1:500 Western Blot: ATRX Antibody [NBP1-32851] - Whole cell extracts (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with ATRX antibody diluted by 1:1000. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB IHC-P Image Rad54 antibody [C3], C-term detects Rad54 protein at nucleus on human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. Rad54 antibody [C3], C-term , dilution: 1:500. IHC-P Image Rad54 antibody [C3], C-term detects Rad54 protein at nucleus on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Rad54 antibody [C3], C-term , dilution: 1:500. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert IF, ELISA Immunofluorescence analysis of A549 cells, using ATRX Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert FACS, WB RAD54 Antibody (C-term) (ABIN655910) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the RAD54 antibody detected the RAD54 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human glioma shows strong nuclear immunoreactivity in tumor cells. Immunohistochemistry: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human liver shows no positivity 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Hund Kaninchen Unkonjugiert WB Host: Rabbit Target Name: ATRX Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/ml  ATRX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: ATRX Antibody (60.1) [NBP1-02823] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert WB Western blot of ATRX antibody. Nuclear extract of CCF-STGG1 cells (40 µg per lane) probed with ATRX antibody (pAb) at a dilution of 1:2,500. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details

ATRX Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Rat (Rattus)


Am meisten referenzierte anti-ATRX Antikörper

  1. Human Polyclonal ATRX Primary Antibody für IHC, IHC (p) - ABIN4282398 : Heaphy, de Wilde, Jiao, Klein, Edil, Shi, Bettegowda, Rodriguez, Eberhart, Hebbar, Offerhaus, McLendon, Rasheed, He, Yan, Bigner, Oba-Shinjo, Marie, Riggins, Kinzler, Vogelstein, Hruban, Maitra et al.: Altered telomeres in tumors with ATRX and DAXX mutations. ... in Science (New York, N.Y.) 2011 (PubMed)
    Show all 16 Pubmed References

  2. Human Polyclonal ATRX Primary Antibody für ICC, IF - ABIN442805 : Wille, Maurer, Piatti, Whittle, Rieder, Singewald, Lusser: Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. in Frontiers in behavioral neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen ATRX Interaktionspartner

Human helicase 2, X-linked (ATRX) Interaktionspartner

  1. ATRX mutation was identified in 2/5 (40%) cases with mosaic staining while one case showed DAXX (zeige DAXX Antikörper) mutation. All these cases were characterized by distinctly separate immune-negative and positive/intermixed foci.

  2. ATRX deficiency was mutually exclusive with LOH. Conversely, ATRX-proficient tumours immunoreactive for R132H-mutant isocitrate dehydrogenase 1 (IDH1 (zeige IDH1 Antikörper)) showed a high rate (85%) of LOH.

  3. Nuclear ATRX loss, either complete or heterogeneous, is encountered in a considerable number of high-grade sarcomas with non-specific genetic alterations.

  4. data suggest that the presence of ATRX at telomeres may have a central role in suppressing deleterious DNA secondary structures that form at transcribed telomeric repeats, and this may account for the increased DNA damage, stalling of replication and homology-directed repair previously observed upon loss of ATRX function

  5. Both primary Alternative lengthening of telomeres(ALT) -positive and ATRX/DAXX (zeige DAXX Antikörper)-negative PanNETs are independently associated with aggressive clinicopathologic behavior and displayed reduced recurrence-free survival. In contrast, ALT activation and loss of ATRX/DAXX (zeige DAXX Antikörper) are both associated with better overall survival in patients with metastases

  6. Whole-exome sequencing has identified recurrent mutations in the genes DAXX (zeige DAXX Antikörper) and ATRX, which correlate with loss of protein expression and alternative lengthening of telomeres (ALT).ALT and DAXX (zeige DAXX Antikörper)/ATRX loss in PanNETs was associated with shorter disease-free survival (DFS (zeige FST Antikörper)) and disease-specific survival (DSS (zeige NR0B1 Antikörper)) and likely plays a significant role in driving metastatic disease

  7. The results of this study support an important role for ATRX loss and acquisition of ALT in the biology of NF1 (zeige NF1 Antikörper)-associated gliomas, particularly diffuse and high-grade tumors developing in adults.

  8. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX (zeige DAXX Antikörper)) prime alternative lengthening of telomeres activation by disrupting telomeric heterochromatin.

  9. Structural and biochemical characterization of DAXX (zeige DAXX Antikörper)-ATRX interaction.

  10. Structural basis for DAXX (zeige DAXX Antikörper) interaction with ATRX.

Mouse (Murine) helicase 2, X-linked (ATRX) Interaktionspartner

  1. PML (zeige PML Antikörper) protein organizes heterochromatin domains where it regulates histone H3.3 (zeige H3F3A Antikörper) deposition by ATRX and DAXX (zeige DAXX Antikörper).

  2. Gene expression changes in the Atrx-null retina indicate defective synaptic structure and neuronal circuitry, suggest excitotoxic mechanisms of neurodegeneration, and demonstrate that common targets of ATRX in the forebrain and retina may contribute to similar neuropathological processes underlying cognitive impairment and visual dysfunction in ATR-X syndrome.

  3. mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory.

  4. The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (zeige PARP1 Antikörper) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

  5. The long noncoding RNA, TERRA (zeige DMRT2 Antikörper) can bind both in cis (zeige CISH Antikörper) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (zeige DMRT2 Antikörper) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (zeige DMRT2 Antikörper) activates, ATRX represses gene expression.

  6. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  7. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  8. Daxx (zeige DAXX Antikörper) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (zeige HELLS Antikörper) levels are low.

  9. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  10. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

ATRX Antigen-Profil

Protein Überblick

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Genbezeichner und Symbole assoziert mit ATRX

  • ATRX, chromatin remodeler (ATRX) Antikörper
  • ATRX, chromatin remodeler (Atrx) Antikörper
  • alpha thalassemia/mental retardation syndrome X-linked L homeolog (atrx.L) Antikörper
  • alpha thalassemia/mental retardation syndrome X-linked homolog (human) (atrx) Antikörper
  • 4833408C14Rik Antikörper
  • AI447451 Antikörper
  • ATR2 Antikörper
  • atrx Antikörper
  • atrxl Antikörper
  • DXHXS6677E Antikörper
  • HP1-BP38 Antikörper
  • Hp1bp2 Antikörper
  • Hp1bp38 Antikörper
  • JMS Antikörper
  • MRXHF1 Antikörper
  • MRXS3 Antikörper
  • rad54 Antikörper
  • RAD54L Antikörper
  • SFM1 Antikörper
  • SHS Antikörper
  • wu:fb26e12 Antikörper
  • wu:fb52h08 Antikörper
  • wu:fb72g09 Antikörper
  • wu:fb94e07 Antikörper
  • XH2 Antikörper
  • Xnp Antikörper
  • zgc:66223 Antikörper
  • ZNF-HX Antikörper

Bezeichner auf Proteinebene für ATRX

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog)

GENE ID SPEZIES
546 Homo sapiens
22589 Mus musculus
246284 Rattus norvegicus
449625 Pan troglodytes
100455265 Pongo abelii
733229 Xenopus laevis
323299 Danio rerio
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