anti-Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) Antikörper

The protein encoded by VPS13A may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Ratte VPS13A VPS13A 309243  
VPS13A 23230 Q96RL7
Anti-Maus VPS13A VPS13A 271564 Q5H8C4
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p) Immunohistochemical staining of human duodenum with VPS13A polyclonal antibody  shows strong granular cytoplasmic positivity in glandular cells. 100 μL 11 bis 12 Tage
$577.33
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Human Kaninchen Unkonjugiert IHC, WB   100 μL 11 bis 14 Tage
$551.83
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Human Kaninchen Unkonjugiert EIA, IHC (fro), WB   0.2 mL 6 bis 8 Tage
$511.50
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Human Kaninchen Unkonjugiert ELISA, IF, WB   100 μL 6 bis 7 Tage
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Am meisten referenzierte anti-Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) Antikörper

  1. Human Polyclonal VPS13A Primary Antibody für IHC, IHC (p) - ABIN4298101 : Sasaki, Nakamura, Kodama, Urata, Shiokawa, Hayashi, Sano: Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal VPS13A Primary Antibody für ICC, IF - ABIN4298102 : Morisaki, Yashiro, Kakehashi, Inagaki, Kinoshita, Fukuoka, Kasashima, Masuda, Sakurai, Kubo, Muguruma, Ohira, Wanibuchi, Hirakawa: Comparative proteomics analysis of gastric cancer stem cells. in PLoS ONE 2014 (PubMed)

Weitere Antikörper gegen Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) Interaktionspartner

Human Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) Interaktionspartner

  1. human VPS13A and VPS13C bind to the ER, tethering it to mitochondria (VPS13A), to late endosome/lysosomes (VPS13C), and to lipid droplets (both VPS13A and VPS13C).

  2. VPS13A localizes at the interface between mitochondria-endosomes and mitochondria-endoplasmic reticulum and that the presence of membrane contact sites is altered in the absence of VPS13A.

  3. Even though these are long noted disease conditions, we still know only little on the underlying disease mechanisms. The current review focuses upon Chorea-Acanthocytosis as the core entity of Neuroacanthocytosis syndromes caused by mutations in the VPS13A gene

  4. Expression of cancer-specific glycan epitopes represents an excellent opportunity for diagnostics and potentially specific detection of tumors. Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls.

  5. These results suggest that PI3P regulates the functioning of Vps13, both in protein trafficking and actin cytoskeleton organization. Attenuation of PI3P-binding ability in the mutant hVps13A protein may be one of the reasons for its mislocalization and disrupted function in cells of patients suffering from chorea-acanthocytosis .

  6. Chorein is a stimulator of Orai1 expression and thus of store operated Ca2+ entry.

  7. Patients with chorea-acanthocytosis carrying a VPS13A mutation present with focal, treatment-resistant seizures.

  8. Defective chorein is accompanied by significant structural disorganization of all cytoskeletal structures.

  9. VPS13A-depleted cells showed accumulation of autophagic markers and impaired autophagic flux

  10. Chorein is expressed in various cancer cells. In cells with high chorein expression levels chorein silencing promotes apoptotic cell death, an effect paralleled by down-regulation of PI-3K activity and BCL-2/Bax expression ratio.

  11. Discovery of new mutations may clarify the pathogenic roles of chorein in chorea-acanthocytosis as well as in the retina

  12. chorein interacts with beta-adducin and beta-actin.

  13. Data indicate functions of chorein, i.e., regulation of secretion and aggregation of blood platelets.

  14. This study demonistrated that neuroacanthocytosis disorders has heterozygotes for mutations in the VPS13A gene.

  15. Results reveal chorein as a novel powerful regulator of cytoskeletal architecture and cell survival, thus explaining erythrocyte misshape and possibly neurodegeneration in chorea-acanthocytosis.

  16. these results suggest that chorein is involved in exocytosis of dense-core vesicles.

  17. Frameshift mutations of VPS genes and losses of expression of Vps13A and Vps35 proteins are common in gastric cancers and colorectal cancers with high microsatellite instability.

  18. identified 36 pathogenic mutations of VPS13A, 20 of which were previously unreported, including two novel copy number variations

  19. A mutation was identified in the VPS13A gene, responsible for autosomal recessive chorea-acanthocytosis.

  20. Founder mutation and single-nucleotid epolymorphisms in chorea-acanthocytosis in French-Canadians.

Mouse (Murine) Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) Interaktionspartner

  1. chorein interacts with beta-adducin and beta-actin.

  2. Mouse CHAC cDNA sequence and the exon-intron structures of the CHAC disease gene are identified and a CHAC model mouse produced by a gene-targeting technique.

  3. Brain-specific variants of VPS13A may be involved in the brain-specific pathology of chorea-acanthocytosis.

Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) Antigen-Profil

Protein Überblick

The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit VPS13A

  • vacuolar protein sorting 13 homolog A (Vps13a) Antikörper
  • chorein (EHI_067970) Antikörper
  • Chorein (GL50803_87358) Antikörper
  • vacuolar protein sorting 13 homolog A (VPS13A) Antikörper
  • vacuolar protein sorting 13A (Vps13a) Antikörper
  • 4930425F11 Antikörper
  • 4930516E05Rik Antikörper
  • 4930543C13Rik Antikörper
  • 9930023P20 Antikörper
  • Chac Antikörper
  • Chorein Antikörper
  • D330038K10Rik Antikörper
  • mKIAA0986 Antikörper
  • RGD1311340 Antikörper

Bezeichner auf Proteinebene für VPS13A

vacuolar protein sorting 13 homolog A , chorein , vacuolar protein sorting 13A , Chorein , vacuolar protein sorting 13 homolog A (S. cerevisiae) , chorea-acanthocytosis protein , vacuolar protein sorting-associated protein 13A , chorea-acanthocytosis protein homolog , hypothetical protein

GENE ID SPEZIES
309243 Rattus norvegicus
3411085 Entamoeba histolytica HM-1:IMSS
5700841 Giardia lamblia ATCC 50803
464538 Pan troglodytes
23230 Homo sapiens
271564 Mus musculus
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