anti-Ubiquitin Specific Peptidase 28 (USP28) Antikörper

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Zusätzlich bieten wir Ihnen USP28 Proteine (4) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
USP28 57646 Q96RU2
USP28 235323 Q5I043
USP28 315639 D3ZJ96
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Top anti-USP28 Antikörper auf antikoerper-online.de

Showing 10 out of 125 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, IHC   100 μg 6 bis 7 Tage
$429.84
Details
Rind (Kuh) Ziege Unkonjugiert ELISA, IHC, IHC (p) Anti-USP28 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962695 concentration 41396 ug/ml. Anti-USP28 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962695 concentration 41396 ug/ml. 50 μg 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 7.5% SDS PAGE USP28 antibody antibody diluted at 1:500 100 μL 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis USP28 (Phospho-Ser714) using UV treated COS7 whole cell lysates 100 μL 11 bis 12 Tage
$450.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis USP28 (Phospho-Ser67) using UV treated HeLa whole cell lysates 100 μL 11 bis 12 Tage
$450.00
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis USP28 using COS7 whole cell lysates 100 μL 11 bis 12 Tage
$390.77
Details
Rind (Kuh) Ziege Unkonjugiert EIA, IHC (p) Staining of paraffin embedded Human Testis using USP28 antibody at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg 6 bis 8 Tage
$445.50
Details
Human Kaninchen Unkonjugiert WB Antibody is used in Western blot to detect USP28 in Jurkat cell lysate. 400 μL 2 bis 3 Tage
$515.63
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg 2 bis 3 Tage
$515.63
Details

Am meisten referenzierte anti-USP28 Antikörper

  1. Human Polyclonal USP28 Primary Antibody für ELISA, WB - ABIN545143 : Valero, Bayés, Francisca Sánchez-Font, González-Angulo, Gonzàlez-Duarte, Marfany: Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. in Genome biology 2001 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal USP28 Primary Antibody für ELISA - ABIN548119 : Popov, Herold, Llamazares, Schülein, Eilers: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. in Cell cycle (Georgetown, Tex.) 2007 (PubMed)

  3. Human Polyclonal USP28 Primary Antibody für ICC, IF - ABIN4364574 : Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012 (PubMed)

Weitere Antikörper gegen USP28 Interaktionspartner

Human Ubiquitin Specific Peptidase 28 (USP28) Interaktionspartner

  1. consequential impacts of USP28-mediated stabilization of LIN28A protein on enhancing cancer cell viability, migration and ultimately augmenting LIN28A-mediated tumor progression. Overall, these data suggest that a synergistic, combinatorial approach of targeting LIN28A with USP28 would contribute to effective cancer therapeutics.

  2. We confirm oligomeric states of USP25 and USP28 in cells and show that modulating oligomerization affects substrate stabilization in accordance with in vitro activity data

  3. Our work led to the identification of significant differences between USP25 and USP28 and provided the molecular basis for the development of new and highly specific anti-cancer drugs

  4. USP28 enhances MAPK activity through the stabilization of RAF family members and is a key factor in BRAF inhibitor resistance.

  5. Lack of USP28 promotes a more malignant state of breast cancer cells, indicated by an epithelial-to-mesenchymal (EMT) transition, elevated proliferation, migration, and angiogenesis as well as a decreased adhesion.

  6. The authors identified 53BP1 and USP28 as essential components acting upstream of p53, evoking p21-dependent cell cycle arrest in response not only to centrosome loss, but also to other distinct defects causing prolonged mitosis.

  7. USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP)

  8. 53BP1-USP28 cooperation is essential for normal p53-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.

  9. USP28-53BP1-p53-p21 signaling pathway is also required to arrest cell growth after a prolonged prometaphase.

  10. analysis of centrinone resistance identified a 53BP1-USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly.

  11. These results showed that USP28 is overexpressed in human glioblastomas and it contributes to glioma tumorigenicity.

  12. Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR-4295.

  13. findings provide a first insight into understanding how the enzymatic activity of Usp28 is regulated by its non-catalytic UBR and endogenous ligands.

  14. Dual regulation of Fbw7 activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28.

  15. identified Usp28 as a c-MYC target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC form a positive feedback loop that maintains high c-MYC protein levels in tumors

  16. USP28 has a chain preference activity for Lys(11), Lys(48), and Lys(63) diubiquitin linkages

  17. Usp28 expression was indentified as a independent predictors of survival (P = 0.001) and potentially valuable in prognostic evaluation of bladder cancer

  18. Study reveals a critical mechanism underlying the epigenetic regulation by USP28.

  19. USP28 is not a critical factor in double-strand break metabolism and is unlikely to be an attractive target for therapeutic intervention aimed at chemotherapy sensitization.

  20. USP28 gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

Mouse (Murine) Ubiquitin Specific Peptidase 28 (USP28) Interaktionspartner

  1. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28, modulate intestinal homeostasis and cancer.

  2. Dual regulation of Fbw7 activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28.

  3. identified Usp28 as a c-MYC target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC form a positive feedback loop that maintains high c-MYC protein levels in tumors

USP28 Antigen-Profil

Protein Überblick

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).

Genbezeichner und Symbole assoziert mit USP28

  • ubiquitin specific peptidase 28 (USP28) Antikörper
  • ubiquitin specific peptidase 28 (usp28) Antikörper
  • ubiquitin specific peptidase 28 (Usp28) Antikörper
  • 9830148O20Rik Antikörper
  • AU022237 Antikörper
  • im:7138195 Antikörper
  • mKIAA1515 Antikörper
  • USP28 Antikörper

Bezeichner auf Proteinebene für USP28

ubiquitin specific peptidase 28 , ubiquitin carboxyl-terminal hydrolase 28-like , ubiquitin specific protease 28 , ubiquitin carboxyl-terminal hydrolase 28 , deubiquitinating enzyme 28 , ubiquitin carboxyl-terminal hydrolase 28 variant 1 , ubiquitin thioesterase 28 , ubiquitin thiolesterase 28 , ubiquitin-specific-processing protease 28

GENE ID SPEZIES
100032176 Monodelphis domestica
100402269 Callithrix jacchus
100468031 Ailuropoda melanoleuca
100492386 Xenopus (Silurana) tropicalis
567050 Danio rerio
696672 Macaca mulatta
100232055 Taeniopygia guttata
100346849 Oryctolagus cuniculus
100558297 Anolis carolinensis
100591669 Nomascus leucogenys
508902 Bos taurus
57646 Homo sapiens
235323 Mus musculus
489400 Canis lupus familiaris
100519614 Sus scrofa
315639 Rattus norvegicus
428246 Gallus gallus
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