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UPF3B encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
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Cow (Bovine) Polyclonal UPF3B Primary Antibody für IHC, WB - ABIN2776563
Lehner, Sanderson: A protein interaction framework for human mRNA degradation. in Genome research 2004
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
, nonsense mRNA reducing factor 3B
, regulator of nonsense transcripts 3B
, up-frameshift suppressor 3 homolog B
, up-frameshift suppressor 3 homolog on chromosome X