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U2AF1 belongs to the splicing factor SR family of genes. Zusätzlich bieten wir Ihnen U2AF1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 45 products:
Human Polyclonal U2AF1 Primary Antibody für ICC, IF - ABIN438948
Wang, Wilson-Berry, Schedl, Hansen: TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. in Developmental dynamics : an official publication of the American Association of Anatomists 2012
Human Polyclonal U2AF1 Primary Antibody für ICC, IF - ABIN4363831
Stadler, Fagerberg, Sivertsson, Oksvold, Zwahlen, Hallström, Lundberg, Uhlén: RNA- and antibody-based profiling of the human proteome with focus on chromosome 19. in Journal of proteome research 2014
The U2AF35(S34F) mutation alters interaction with CFIm59 (zeige CPSF7 Antikörper), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 (zeige ATG7 Antikörper) pre-mRNA, decreasing levels of ATG7 (zeige ATG7 Antikörper) protein and defective autophagy, ultimately leading to transformation.
data support the impact of genes from the Abcg1 (zeige ABCG1 Antikörper)-U2af1 region as modifiers of Tc1 (zeige C8orf4 Antikörper)-dependent memory and locomotor phenotypes in Tc1 (zeige C8orf4 Antikörper) mouse model of Down syndrome.
findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS (zeige MECOM Antikörper)
this study establishes definitely the contribution of the Abcg1 (zeige ABCG1 Antikörper)-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memory.
data confirm MLL (zeige MLL Antikörper)-PTD (zeige BCS1L Antikörper) and, to a lesser extent, FLT3 (zeige FLT3 Antikörper)-ITD as common events in +11 AML (zeige RUNX1 Antikörper).6, 7, 8 However, the high mutation frequencies of U2AF1 and genes involved in methylation (DNMT3A (zeige DNMT3A Antikörper), IDH2 (zeige IDH2 Antikörper)) have hitherto not been reported in +11 AML (zeige RUNX1 Antikörper)
this study characterized novel candidate pediatric T-cell acute lymphoblastic leukemia driver mutation in splicesome factor U2AF1
U2AF35 missense mutation is associated with alternative 5' splice site that impacts splicing regulation in cancer.
The frequently mutated SF3B1 (zeige SF3B2 Antikörper) residues contact the pre-mRNA splice site. Based on structural homology with other spliceosome subunits, and recent findings of altered RNA binding by mutant U2AF1 proteins, we suggest that affected U2AF1 residues also contact pre-mRNA.
The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor (zeige SLU7 Antikörper) genes in myelodysplastic syndromes (SF3B1 (zeige SF3B2 Antikörper), SRSF2 (zeige SRSF2 Antikörper) and U2AF1) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)
infer that U2AF1 S34 mutations characterize a distinct subgroup of myelodysplastic syndrome
Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons controlled by SRF3.
Our results provide mechanistic explanations of the magnitude of splicing changes observed in U2AF1-mutant cells and why tumors harboring U2AF1 mutations always retain an expressed copy of the wild-type allele
Mutations in ASXL1 (zeige ASXL1 Antikörper), U2AF1, and SF3B1 (zeige SF3B2 Antikörper) are common in Chinese patients with myelodysplastic syndromes.
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
U2 small nuclear RNA auxiliary factor 1
, RNA recognition motif-containing protein RRM
, RNA-binding region RNP-1 domain-containing protein
, U2 snRNP auxiliary factor small subunit
, U2(RNU2) small nuclear RNA auxiliary factor 1
, U2 auxiliary factor 35 kDa subunit
, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa
, splicing factor U2AF 35 kDa subunit
, U2 small nuclear RNA auxillary factor 1
, U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
, U2(RNU2) small nuclear RNA auxiliary factor binding protein
, splicing factor U2AF 35kDa subunit
, U2snRNP auxiliary factor small subunit
, uncharacterized protein LOC687575
, U2(RNU2) small nuclear RNA auxillary factor 1