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TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. Zusätzlich bieten wir Ihnen TPCN2 Proteine (5) und TPCN2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal TPCN2 Primary Antibody für ELISA - ABIN4250202
Calcraft, Ruas, Pan, Cheng, Arredouani, Hao, Tang, Rietdorf, Teboul, Chuang, Lin, Xiao, Wang, Zhu, Lin, Wyatt, Parrington, Ma, Evans, Galione, Zhu: NAADP mobilizes calcium from acidic organelles through two-pore channels. in Nature 2009
Human Polyclonal TPCN2 Primary Antibody für IHC, ELISA - ABIN2687105
Lee, Tong, Cheng, Hung, Cheung: Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology. in Scientific reports 2016
localized calcium (Ca(2 (zeige CA2 Antikörper)+)) release via TPC2 might trigger the generation of more global Ca(2 (zeige CA2 Antikörper)+) release from the sarcoplasmic reticulum via Ca(2 (zeige CA2 Antikörper)+)-induced Ca(2 (zeige CA2 Antikörper)+) release.
TPC2-mediated Ca(2 (zeige CA2 Antikörper)+) release from lysosomes may act upstream from RyR (zeige RYR1 Antikörper)- and IP 3R-mediated Ca(2 (zeige CA2 Antikörper)+) release, suggesting that the former might initiate the SR-mediated Ca(2 (zeige CA2 Antikörper)+)-induced-Ca(2 (zeige CA2 Antikörper)+)-release essential for SMC (zeige DYM Antikörper) myogenesis and function.
These findings indicate potential differential regulation of signaling processes by TPC1 (zeige TPCN1 Antikörper) and TPC2 in breast cancer cells.
TPC2 regulates pigmentation through two fundamental determinants of melanosome function: pH and size.
Results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2.
Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 (zeige NPC1 Antikörper) and TPC2.
Studies suggest that both two-pore channels TPC1 (zeige TPCN1 Antikörper) and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.
TPC2 is thus a potential drug target within a pathogenic LRRK2 cascade that disrupts Ca(2 (zeige CA2 Antikörper)+)-dependent trafficking in Parkinson disease
SNPs within Tpcn2 are associated with fasting insulin in humans.
NAADP induced marked Ca(2 (zeige CA2 Antikörper)+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits
TPC2, but not TPC1 (zeige TPCN1 Antikörper), caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.
These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis
High TPC2 expression is associated with lung metastasis in breast cancer.
Electron micrographs of hearts from TPC1 (zeige TPCN1 Antikörper)/TPC2 double knockout mice showed that cardiomyocytes contained large numbers of immature lysosomes compared to wild-type mice.
observations define a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major contributors in the acute actions of beta-adrenergic signaling in the heart
TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and in fatty liver disease.
Genetic ablation of endolysosomal TPC1 (zeige TPCN1 Antikörper) or TPC2 channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2 (zeige CA2 Antikörper)+ signals, and insulin (zeige INS Antikörper) secretion in pancreatic beta cells.
Tpcn2 knockout mice demonstrated a significant decrease in fasting glucose levels and insulin (zeige INS Antikörper) response to a glucose challenge.
Mice lacking TPC2 display muscle atrophy and altered autophagy.
It was concluded that Tpcn1 (zeige TPCN1 Antikörper)/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.
Findings indicate that TPC2 have important but distinct roles from TPC1 (zeige TPCN1 Antikörper) in the endo-lysosomal pathway.
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
two pore calcium channel protein 2
, voltage-dependent calcium channel protein TPC2
, two pore segment channel 2
, two pore calcium channel protein 2-like
, two-pore calcium channel protein 2