anti-Tumor Protein P63 (TP63) Antikörper

TP63 encodes a member of the p53 family of transcription factors. Zusätzlich bieten wir Ihnen p63 Kits (31) und p63 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
TP63 22061 O88898
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Top anti-p63 Antikörper auf

Showing 10 out of 77 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IHC (p), WB Anti-p63 Picoband antibody,  IHC(P): Human Oesophagus Squama Cancer Tissue Anti-p63 Picoband antibody,  All lanes: Anti P63  at 0.5ug/ml WB: Recombinant Human P63 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
Human Kaninchen Unkonjugiert WB TP63 Antibody (C-term) (ABIN657886) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the TP63 antibody detected the TP63 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert ICC, IHC (p), WB Anti-p63 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Anti-p63 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: SMMC Cell Lysate Lane 3: COLO320 Cell Lysate Lane 4: A549 Cell Lysate Lane 5: SGC Cell Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemistry of paraffin-embedded rat kidney using TP63 antibody at dilution of 1:100 (x400 lens). 100 μL Anmelden zum Anzeigen 16 Days
Human Maus Unkonjugiert WB TP63 Antibody (Ascites) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TP63 antibody detected the TP63 protein (arrow). 0.1 mL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert IHC (p) Immunochemical staining of human P63 in human skin with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human P63 in human prostate with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
Human Kaninchen Unkonjugiert WB Human p63 / TP63 Western blot (WB) 13067 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged TP73L is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
Human Kaninchen Unkonjugiert IHC (p) Immunochemical staining of human P63 in human prostatic carcinoma with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human P63 in human prostate with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Anmelden zum Anzeigen 20 bis 21 Tage

TP63 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , ,
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Rat (Rattus) ,
Mouse (Murine) ,

Am meisten referenzierte anti-p63 Antikörper

  1. Human Monoclonal p63 Primary Antibody für IHC, WB - ABIN2673817 : Zhang, Wei, Dang, Xie, Zhong, Ma, Chen: Primary urinary bladder adenosquamous carcinoma complicated with lower limb deep venous thromboses: a case report. in International journal of clinical and experimental pathology 2015 (PubMed)

  2. Human Polyclonal p63 Primary Antibody für WB - ABIN657886 : Miki, Kubo, Takahashi, Yoon, Kim, Lee, Zo, Lee, Hosono, Morizono, Tsunoda, Kamatani, Chayama, Takahashi, Inazawa, Nakamura, Daigo: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. in Nature genetics 2010 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen p63 Interaktionspartner

Human Tumor Protein P63 (TP63) Interaktionspartner

  1. findings illustrate that DeltaNp63alpha can inhibit the levels of LIF (zeige LIF Antikörper) mRNA by direct transcription regulation and decrease LIF (zeige LIF Antikörper) mRNA stability by suppressing the expression of Lnc-LIF (zeige LIF Antikörper)-AS. An inverse interaction of LIF (zeige LIF Antikörper) and DeltaNp63alpha expression was as well validated in clinical samples of cervical cancer, and high level of LIF (zeige LIF Antikörper) in cervical cancers was related with poor patient survival.

  2. Negative staining for CK5 (zeige KRT5 Antikörper)/6 and p63 (zeige RPE65 Antikörper) can be helpful to distinguish Well-differentiated neuroendocrine tumors (WDNETs) from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low-grade tumors may be the first sign of aggressive metastatic disease

  3. EGFR (zeige EGFR Antikörper) pathway gene expression analysis indicated that DeltaNp63 alters EGFR (zeige EGFR Antikörper)-regulated genes involved in cell adhesion, migration, and angiogenesis. Addition of EGF (zeige EGF Antikörper) or neutralizing EGFR (zeige EGFR Antikörper) antibodies demonstrated that EGFR (zeige EGFR Antikörper) activation is responsible for DeltaNp63-mediated loss of cellular adhesion

  4. SNHG1 might play an oncogenic role in SCC (zeige CYP11A1 Antikörper) through ZEB1 (zeige ZEB1 Antikörper) signaling pathway by inhibiting TAp63.

  5. This review discusses the evidence of DeltaNp63alpha as a master regulator of epithelial-mesenchymal transition (EMT (zeige ITK Antikörper)) components and miRNA, highlighting the need for a deeper understanding of its role in EMT (zeige ITK Antikörper).[review]

  6. miR (zeige MLXIP Antikörper)-223-5p overexpression is a putative pathological mechanism of tumor invasion and a promising therapeutic target; both miR (zeige MLXIP Antikörper)-223-5p and p63 (zeige RPE65 Antikörper) may be prognostic factors in vulvar cancer

  7. miR (zeige MLXIP Antikörper)-133b plays an important role in the anti-tumor effects of TAp63 in colorectal cancer.

  8. Data show that a dominant-negative effect is widely spread within the p53 (zeige TP53 Antikörper)/p63 (zeige RPE65 Antikörper)/p73 (zeige TP73 Antikörper) family as all p53 (zeige TP53 Antikörper) loss-of-function hotspot mutants and several of the isoforms of p53 (zeige TP53 Antikörper) and p73 (zeige TP73 Antikörper) tested exhibit a dominant-negative potential.

  9. As a transcriptionally regulated program, urothelial differentiation operates as a heterarchy, wherein GATA3 (zeige GATA3 Antikörper) is able to co-operate with FOXA1 (zeige FOXA1 Antikörper) to drive expression of luminal marker genes, but that P63 (zeige RPE65 Antikörper) has potential to transrepress expression of the same genes.

  10. the majority of cells within the tumor appears to express predominantly TAp63 isoform. While DeltaNp63 exerts its effects by regulating a PI3K (zeige PIK3CA Antikörper)/CD44v6 pathway.

Horse (Equine) Tumor Protein P63 (TP63) Interaktionspartner

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Zebrafish Tumor Protein P63 (TP63) Interaktionspartner

  1. they unravel essential roles of TAp63 and p53 (zeige TP53 Antikörper) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (zeige NOTCH1 Antikörper) signalling and caspase 3 (zeige CASP3 Antikörper) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (zeige BBC3 Antikörper) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (zeige RPS19 Antikörper)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (zeige TP53 Antikörper) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Mouse (Murine) Tumor Protein P63 (TP63) Interaktionspartner

  1. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (zeige IL31 Antikörper) and IL-33 (zeige IL33 Antikörper) are key players in the signaling pathways.

  2. cells expressing both p63 (zeige CKAP4 Antikörper) and p73 (zeige ARHGAP24 Antikörper) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.

  3. Data suggest that this the selective targeting of genes by tumor suppressor protein (zeige TP53 Antikörper) p63 (p63 (zeige CKAP4 Antikörper)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.

  4. p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Antikörper) expression via E2F1 transcription factor (zeige E2F1 Antikörper) 1 (zeige HNF1A Antikörper), promoting Wasf3/Wave3 (zeige WASF3 Antikörper)/MMP9 (zeige MMP9 Antikörper) signaling and bladder cancer invasion

  5. these results therefore highlight an unanticipated role for p53 (zeige TP53 Antikörper) family proteins in a regulatory network that integrates essential Wnt (zeige WNT2 Antikörper)-Tcf (zeige HNF4A Antikörper) and nodal-Smad (zeige SMAD1 Antikörper) inputs.

  6. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (zeige TP53 Antikörper) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

  7. TGFb3 (zeige TGFB3 Antikörper)-induced down-regulation of p63 (zeige CKAP4 Antikörper) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.

  8. miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.

  9. Taken together, these data show that p63 (zeige CKAP4 Antikörper) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.

  10. IL-6 (zeige IL6 Antikörper)/P-STAT3 (zeige STAT3 Antikörper) activation influences p63 (zeige CKAP4 Antikörper) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

Xenopus laevis Tumor Protein P63 (TP63) Interaktionspartner

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (zeige BMP4 Antikörper).

  3. The role of p63 as a negative Wnt (zeige WNT2 Antikörper)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Antigen-Profil

Protein Überblick

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Genbezeichner und Symbole assoziert mit TP63

  • tumor protein p63 (TP63) Antikörper
  • tumor protein p63 (tp63) Antikörper
  • tumor protein p63 (Tp63) Antikörper
  • transformation related protein 63 (Trp63) Antikörper
  • tumor protein p63 L homeolog (tp63.L) Antikörper
  • AI462811 Antikörper
  • AIS Antikörper
  • B(p51A) Antikörper
  • B(p51B) Antikörper
  • DNp63 Antikörper
  • EEC3 Antikörper
  • id:ibd3516 Antikörper
  • ket Antikörper
  • LMS Antikörper
  • NBP Antikörper
  • np63 Antikörper
  • OFC8 Antikörper
  • p40 Antikörper
  • p51 Antikörper
  • P51/P63 Antikörper
  • p53CP Antikörper
  • P63 Antikörper
  • p73H Antikörper
  • P73l Antikörper
  • RHS Antikörper
  • SHFM4 Antikörper
  • TP53CP Antikörper
  • TP53L Antikörper
  • Tp63 Antikörper
  • Tp73l Antikörper
  • tp73l-A Antikörper
  • Trp53rp1 Antikörper
  • trp63 Antikörper
  • wu:fc89f04 Antikörper
  • wu:fk85h07 Antikörper
  • wu:fk88b02 Antikörper
  • Xp63 Antikörper

Bezeichner auf Proteinebene für TP63

CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , tumor protein p63 , delta-Np63 , fc89f04 , transformation related protein 63 , tumor protein 63 kDa , tumor protein 63-like

8626 Homo sapiens
100059752 Equus caballus
100170632 Oryzias latipes
260407 Danio rerio
703997 Macaca mulatta
615335 Bos taurus
246334 Rattus norvegicus
374269 Gallus gallus
460930 Pan troglodytes
488125 Canis lupus familiaris
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100444448 Pongo abelii
100606847 Nomascus leucogenys
22061 Mus musculus
373640 Xenopus laevis
100625258 Sus scrofa
100355881 Oryctolagus cuniculus
100732143 Cavia porcellus
101108874 Ovis aries
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