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TP63 encodes a member of the p53 family of transcription factors. Zusätzlich bieten wir Ihnen p63 Kits (31) und p63 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal p63 Primary Antibody für WB - ABIN657886
Miki, Kubo, Takahashi, Yoon, Kim, Lee, Zo, Lee, Hosono, Morizono, Tsunoda, Kamatani, Chayama, Takahashi, Inazawa, Nakamura, Daigo: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. in Nature genetics 2010
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Human Monoclonal p63 Primary Antibody für IHC, WB - ABIN2673817
Zhang, Wei, Dang, Xie, Zhong, Ma, Chen: Primary urinary bladder adenosquamous carcinoma complicated with lower limb deep venous thromboses: a case report. in International journal of clinical and experimental pathology 2015
that both major p63 (zeige RPE65 Antikörper) protein isoforms are expressed in triple-negative breast cancers with different tumour characteristics, indicating distinct functional activities of p63 (zeige RPE65 Antikörper) variants in breast cancer
Wnt5a (zeige WNT5A Antikörper)-Ror2 (zeige ROR2 Antikörper) signaling enhanced tongue SCC (zeige CYP11A1 Antikörper) cell aggressiveness and promoted production of MMP-2 (zeige MMP2 Antikörper) following DeltaNp63beta-mediated EMT (zeige ITK Antikörper)
p63 (zeige RPE65 Antikörper)-DBD is capable of binding to anti-apoptotic BclxL (zeige BCL2L1 Antikörper) via its DNA binding interface, a feature that has only been shown for p53 (zeige TP53 Antikörper) so far.
The data indicate that EPCR (zeige PROCR Antikörper) can regulate p63 (zeige RPE65 Antikörper), is associated with highly proliferative keratinocytes, and is a potential human epidermal stem cell marker.
miR (zeige MLXIP Antikörper)-124 regulates p63 (zeige RPE65 Antikörper) via iASPP (zeige PPP1R13L Antikörper), while p63 (zeige RPE65 Antikörper) targets miR (zeige MLXIP Antikörper)-155 via the modulation of STAT1 (zeige STAT1 Antikörper) expression in colorectal cancer.
The number of p63 (zeige RPE65 Antikörper)(+) cells is significantly higher in both hyperplastic (1.53-fold, P < 0.0001) and squamous metaplastic (2.02-fold, P < 0.0001) epithelium from nasal polyps than from healthy controls
In p53 (zeige TP53 Antikörper)-deficient breast cancers, compensatory mechanism of NFkB repression by p63 (zeige RPE65 Antikörper) and p73 (zeige TP73 Antikörper) during genotoxic stress could lead to complex effects that would influence all aspects of tumor progression.
findings illustrate that DeltaNp63alpha can inhibit the levels of LIF (zeige LIF Antikörper) mRNA by direct transcription regulation and decrease LIF (zeige LIF Antikörper) mRNA stability by suppressing the expression of Lnc-LIF (zeige LIF Antikörper)-AS. An inverse interaction of LIF (zeige LIF Antikörper) and DeltaNp63alpha expression was as well validated in clinical samples of cervical cancer, and high level of LIF (zeige LIF Antikörper) in cervical cancers was related with poor patient survival.
Negative staining for CK5 (zeige KRT5 Antikörper)/6 and p63 (zeige RPE65 Antikörper) can be helpful to distinguish Well-differentiated neuroendocrine tumors (WDNETs) from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low-grade tumors may be the first sign of aggressive metastatic disease
EGFR (zeige EGFR Antikörper) pathway gene expression analysis indicated that DeltaNp63 alters EGFR (zeige EGFR Antikörper)-regulated genes involved in cell adhesion, migration, and angiogenesis. Addition of EGF (zeige EGF Antikörper) or neutralizing EGFR (zeige EGFR Antikörper) antibodies demonstrated that EGFR (zeige EGFR Antikörper) activation is responsible for DeltaNp63-mediated loss of cellular adhesion
p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses
they unravel essential roles of TAp63 and p53 (zeige TP53 Antikörper) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (zeige NOTCH1 Antikörper) signalling and caspase 3 (zeige CASP3 Antikörper) activity.
the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (zeige BBC3 Antikörper) transcription in response to ER stress.
Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)
DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)
rps19 (zeige RPS19 Antikörper)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (zeige TP53 Antikörper) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia
Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (zeige IL31 Antikörper) and IL-33 (zeige IL33 Antikörper) are key players in the signaling pathways.
cells expressing both p63 (zeige CKAP4 Antikörper) and p73 (zeige ARHGAP24 Antikörper) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
Data suggest that this the selective targeting of genes by tumor suppressor protein (zeige TP53 Antikörper) p63 (p63 (zeige CKAP4 Antikörper)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.
p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Antikörper) expression via E2F1 transcription factor (zeige E2F1 Antikörper) 1 (zeige HNF1A Antikörper), promoting Wasf3/Wave3 (zeige WASF3 Antikörper)/MMP9 (zeige MMP9 Antikörper) signaling and bladder cancer invasion
these results therefore highlight an unanticipated role for p53 (zeige TP53 Antikörper) family proteins in a regulatory network that integrates essential Wnt (zeige WNT2 Antikörper)-Tcf (zeige HNF4A Antikörper) and nodal-Smad (zeige SMAD1 Antikörper) inputs.
the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (zeige TP53 Antikörper) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.
TGFb3 (zeige TGFB3 Antikörper)-induced down-regulation of p63 (zeige CKAP4 Antikörper) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.
miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.
Taken together, these data show that p63 (zeige CKAP4 Antikörper) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.
IL-6 (zeige IL6 Antikörper)/P-STAT3 (zeige STAT3 Antikörper) activation influences p63 (zeige CKAP4 Antikörper) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (zeige BMP4 Antikörper).
The role of p63 as a negative Wnt (zeige WNT2 Antikörper)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, tumor protein p63
, transformation related protein 63
, tumor protein 63 kDa
, tumor protein 63-like