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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis.
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In African-Americans, higher OPG levels were associated with characteristics common in patients with heart failure with preserved ejection fraction (HFpEF) and were significantly associated with known precursors to HFpEF.
TRACP (zeige ACP5 Proteine)-5b level is significantly associated with the OPG level and with the severity and extent of coronary atherosclerosis in coronary artery disease patients
Vascular smooth cells are a significant source of osteoprotegerin within the vasculature but that RANKL (zeige TNFSF11 Proteine), once present, downregulates this production and appears capable of preventing the "protective" upregulation of OPG seen with VSMCs exposed to physiological levels of cyclic strain.
higher serum OPG levels represent an independent risk factor for cardiovascular and fracture risk.
For the OPG gene, an association was observed between the group with chronic arthralgia and joint TMD (zeige TTN Proteine) and the control group (P=0.04). There was also a tendency towards an association of the haplotype CGCCAA with an increased risk of developing chronic joint pain, even in the absence of TMD (zeige TTN Proteine) (P=0.06).
Vitamin D, tumor necrosis factor (TNF)-alpha (zeige TNF Proteine), receptor activator of nuclear factor-KB ligand (RANKL (zeige TNFSF11 Proteine)), and OPG levels were determined in GCF (zeige GUCY2F Proteine) and serum. Baseline clinical parameters were similar in all periodontitis groups (P > 0.05) but were higher than that in controls
Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell death.
down-regulated miR (zeige MLXIP Proteine)-143-5p promotes the differentiation of DPSCs into odontoblasts by enhancing Runx2 (zeige RUNX2 Proteine) expression via the OPG/RANKL (zeige TNFSF11 Proteine) signaling pathway.
OPG and OPG/TRAIL ratio expression were significantly increased in rheumatoid arthritis patients compared to controls (fold change = 1.79, p = 0.013 and 2.07, p = 0.030, respectively), RANKL/OPG (zeige TNFSF11 Proteine) ratio was significantly decreased (fold change = 0.50, p = 0.020). No significant differences were found between patients and controls in RANKL (zeige TNFSF11 Proteine) and TRAIL expression.
Elevated OPG was a strong and independent predictor of longterm cardiovascular mortality, even after adjustment for traditional risk factors. Low levels of both OPG and act vWF (zeige VWF Proteine) were associated with a 99 % survival rate during the follow-up of five years.
findings demonstrate that mTORC1 activation-stimulated RANKL (zeige TNFSF11 Proteine) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (zeige TNFSF11 Proteine) axis via negative regulation of beta-catenin (zeige CTNNB1 Proteine).
RANK/RANKL (zeige TNFSF11 Proteine) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.
endocortical resorption is driven by reduced OPG (zeige TNFSF11 Proteine) rather than elevated RANKL (zeige TNFSF11 Proteine) expression
Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.
These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (zeige TNFSF11 Proteine) interaction and osteoclastogenesis.
OPG (zeige TNFSF11 Proteine) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.
These data suggested that OPG (zeige TNFSF11 Proteine) played an important role in maintaining the homeostasis of articular cartilage of femoral head.
Data show that p38alpha (zeige MAPK14 Proteine) mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) in paired related homeobox 1 (zeige PRRX1 Proteine) protein (Prx1 (zeige PRDX1 Proteine)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.
OPG (zeige TNFSF11 Proteine) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice
The OPG (zeige TNFSF11 Proteine) expression levels decreased while those of RANKL (zeige TNFSF11 Proteine) and RUNX2 (zeige RUNX2 Proteine) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (zeige TNFSF11 Proteine) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like