Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteine (TNFRSF11B)

Human Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. We conclude that non-small cell lung cancer patients have a higher content of OPG in bronchoalveolar lavage fluid than healthy people.

2. positive correlation of OPG with age and an inverse correlation with IGF-I (zeige IGF1 Proteine) favor the compensatory response of OPG against bone loss in the aging skeleton

3. The results indicated that mice treated with low levels of human recombinant OPG may have a more stable aneurysmal phenotype due to compensatory production of collagen and increased vessel wall thickness of the aorta, potentially protecting the aneurysm from rupture.

4. TNF-alpha (zeige TNF Proteine), DKK1 (zeige DKK1 Proteine), and OPG have roles in pathogenesis of knee osteoarthritis

5. OPG mRNA expression was higher in tumour tissue from patients with metastatic prostate cancer compared to local disease. The RANKL/OPG (zeige TNFSF11 Proteine) ratio was low in normal prostate tissue and high in tumours with bone metastases. Expression was high in BPH (zeige GLI3 Proteine) tissue but did not exceed as much as in the tumour tissue.

6. results of this study concluded that the RANK, RANK-L and OPG system participates in bone remodeling after RME

7. In cardiovascular risks, OPG serum level might increase as a preventive compensatory mechanism to neutralize the RANKL (zeige TNFSF11 Proteine) level increment. The determination of the OPG-RANKL (zeige TNFSF11 Proteine) system is a diagnostic indicator for the intensity of vascular calcification and atherosclerosis in SSc (zeige CYP11A1 Proteine) patients.

8. Demonstrate that rs3134069 in TNFRSF11B increases risk of ischemic stroke by decreasing TNFRSF11B expression.

9. sRANKL and OPG may play a role in the pathogenesis of diabetes as well as metabolic disturbance

10. The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN (zeige SPP1 Proteine), OPG, and BMP2 (zeige BMP2 Proteine) genes in pathogenesis of aortic valve calcification.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. Epithelial rests of Malassez may be associated with root resorption via OPG (zeige TNFSF11 Proteine), thus helping to explain the mechanism underlying root resorption.

2. findings demonstrate that mTORC1 activation-stimulated RANKL (zeige TNFSF11 Proteine) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (zeige TNFSF11 Proteine) axis via negative regulation of beta-catenin (zeige CTNNB1 Proteine).

3. RANK/RANKL (zeige TNFSF11 Proteine) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.

4. endocortical resorption is driven by reduced OPG (zeige TNFSF11 Proteine) rather than elevated RANKL (zeige TNFSF11 Proteine) expression

5. Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.

6. These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (zeige TNFSF11 Proteine) interaction and osteoclastogenesis.

7. OPG (zeige TNFSF11 Proteine) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.

8. These data suggested that OPG (zeige TNFSF11 Proteine) played an important role in maintaining the homeostasis of articular cartilage of femoral head.

9. Data show that p38alpha (zeige MAPK14 Proteine) mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) in paired related homeobox 1 (zeige PRRX1 Proteine) protein (Prx1 (zeige PRDX1 Proteine)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.

10. OPG (zeige TNFSF11 Proteine) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

Rabbit Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. The OPG (zeige TNFSF11 Proteine) expression levels decreased while those of RANKL (zeige TNFSF11 Proteine) and RUNX2 (zeige RUNX2 Proteine) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

2. Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (zeige TNFSF11 Proteine) mRNA expression.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.