Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteine (TNFRSF11B)

Human Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. Studied association between osteoprotegerin gene polymorphisms and osteoporosis in Roma and non-Roma postmenopausal women in Eastern Slovakia.

2. In type 2 diabetes patients HMGB-1 (zeige HMGB1 Proteine) and OPG serum levels are higher in patients affected by peripheral arterial disease and independently associated with its occurrence and clinical severity

3. The epicardial adipose tissue expresses the mRNA of osteopontin (zeige SPP1 Proteine), osteoprotegerin, and osteonectin (zeige SPARC Proteine) genes that have been implicated in the calcification process; such expression is statistically associated with some components of HDL (zeige HSD11B1 Proteine) subclasses in coronary artery disease patients.

4. Serum osteoprotegerin level is significantly associated with both the presence and severity of peripheral arterial disease in patients with type 2 diabetes.

5. Serum osteoprotegerin was the strongest risk factor associated with new development and rapid progression of arterial calcification in incident peritoneal dialysis patients.

6. Osteoprotegerin was associated with chronic kidney disease in hypertensive patients.

7. Data suggest that, in children with type I diabetes, serum levels of osteoprotegerin are up-regulated, serum levels of RANKL (zeige TNFSF11 Proteine) are unchanged, and serum levels of fetuin-A (zeige AHSG Proteine) are down-regulated. (RANKL (zeige TNFSF11 Proteine) = receptor activator of nuclear factor kappa B ligand (zeige TNFSF11 Proteine))

8. Data indicate a significant inverse relationship between plasma osteoprotegerin (OPG) levels and breast cancer risk among women with an inherited BRCA1 or BRCA2 (zeige BRCA2 Proteine) mutation.

9. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin (zeige CALCA Proteine) and osteoprotegerin, whereas the osteocalcin (zeige BGLAP Proteine) expression significantly increased during calcification.

10. Elevated serum ferritin (zeige FTL Proteine) concentrations and bone remodeling marker, osteoprotegerin, are independent predictors of hip fracture in postmenopausal women hospitalized for fragility fracture.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. findings demonstrate that mTORC1 activation-stimulated RANKL (zeige TNFSF11 Proteine) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (zeige TNFSF11 Proteine) axis via negative regulation of beta-catenin (zeige CTNNB1 Proteine).

2. RANK/RANKL (zeige TNFSF11 Proteine) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.

3. endocortical resorption is driven by reduced OPG (zeige TNFSF11 Proteine) rather than elevated RANKL (zeige TNFSF11 Proteine) expression

4. Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.

5. These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (zeige TNFSF11 Proteine) interaction and osteoclastogenesis.

6. OPG (zeige TNFSF11 Proteine) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.

7. These data suggested that OPG (zeige TNFSF11 Proteine) played an important role in maintaining the homeostasis of articular cartilage of femoral head.

8. Data show that p38alpha (zeige MAPK14 Proteine) mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) in paired related homeobox 1 (zeige PRRX1 Proteine) protein (Prx1 (zeige PRDX1 Proteine)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.

9. OPG (zeige TNFSF11 Proteine) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

10. the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice

Rabbit Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. The OPG (zeige TNFSF11 Proteine) expression levels decreased while those of RANKL (zeige TNFSF11 Proteine) and RUNX2 (zeige RUNX2 Proteine) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

2. Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (zeige TNFSF11 Proteine) mRNA expression.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

1. Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.