Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteine (TNFRSF11B)

Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Zusätzlich bieten wir Ihnen Tumor Necrosis Factor Receptor Superfamily, Member 11b Antikörper (192) und Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (103) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNFRSF11B 4982 O00300
TNFRSF11B 18383 O08712
TNFRSF11B 25341 O08727
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Showing 10 out of 49 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HEK-293 Cells Maus Unkonjugiert 25 μg Anmelden zum Anzeigen 10 bis 12 Tage
$148.82
Details
Human Cells Human His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$250.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Human Cells Rhesusaffen Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$272.80
Details
HEK-293 Cells Human His tag Human Osteoprotegerin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$198.00
Details
HEK-293 Cells Human His tag   20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$150.00
Details
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$170.50
Details
Escherichia coli (E. coli) Human Unkonjugiert Validation with Western Blot 50 μg Anmelden zum Anzeigen 8 bis 11 Tage
$218.90
Details
Human Cells Maus Fc Tag SDS-PAGE 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$272.80
Details

TNFRSF11B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , , ,
, , ,
Mouse (Murine) , , , ,
,
Rat (Rattus) ,

Weitere Proteine zu Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartnern

Human Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

  1. We conclude that non-small cell lung cancer patients have a higher content of OPG in bronchoalveolar lavage fluid than healthy people.

  2. positive correlation of OPG with age and an inverse correlation with IGF-I (zeige IGF1 Proteine) favor the compensatory response of OPG against bone loss in the aging skeleton

  3. The results indicated that mice treated with low levels of human recombinant OPG may have a more stable aneurysmal phenotype due to compensatory production of collagen and increased vessel wall thickness of the aorta, potentially protecting the aneurysm from rupture.

  4. TNF-alpha (zeige TNF Proteine), DKK1 (zeige DKK1 Proteine), and OPG have roles in pathogenesis of knee osteoarthritis

  5. OPG mRNA expression was higher in tumour tissue from patients with metastatic prostate cancer compared to local disease. The RANKL/OPG (zeige TNFSF11 Proteine) ratio was low in normal prostate tissue and high in tumours with bone metastases. Expression was high in BPH (zeige GLI3 Proteine) tissue but did not exceed as much as in the tumour tissue.

  6. results of this study concluded that the RANK, RANK-L and OPG system participates in bone remodeling after RME

  7. In cardiovascular risks, OPG serum level might increase as a preventive compensatory mechanism to neutralize the RANKL (zeige TNFSF11 Proteine) level increment. The determination of the OPG-RANKL (zeige TNFSF11 Proteine) system is a diagnostic indicator for the intensity of vascular calcification and atherosclerosis in SSc (zeige CYP11A1 Proteine) patients.

  8. Demonstrate that rs3134069 in TNFRSF11B increases risk of ischemic stroke by decreasing TNFRSF11B expression.

  9. sRANKL and OPG may play a role in the pathogenesis of diabetes as well as metabolic disturbance

  10. The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN (zeige SPP1 Proteine), OPG, and BMP2 (zeige BMP2 Proteine) genes in pathogenesis of aortic valve calcification.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

  1. Epithelial rests of Malassez may be associated with root resorption via OPG (zeige TNFSF11 Proteine), thus helping to explain the mechanism underlying root resorption.

  2. findings demonstrate that mTORC1 activation-stimulated RANKL (zeige TNFSF11 Proteine) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (zeige TNFSF11 Proteine) axis via negative regulation of beta-catenin (zeige CTNNB1 Proteine).

  3. RANK/RANKL (zeige TNFSF11 Proteine) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.

  4. endocortical resorption is driven by reduced OPG (zeige TNFSF11 Proteine) rather than elevated RANKL (zeige TNFSF11 Proteine) expression

  5. Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.

  6. These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (zeige TNFSF11 Proteine) interaction and osteoclastogenesis.

  7. OPG (zeige TNFSF11 Proteine) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.

  8. These data suggested that OPG (zeige TNFSF11 Proteine) played an important role in maintaining the homeostasis of articular cartilage of femoral head.

  9. Data show that p38alpha (zeige MAPK14 Proteine) mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) in paired related homeobox 1 (zeige PRRX1 Proteine) protein (Prx1 (zeige PRDX1 Proteine)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.

  10. OPG (zeige TNFSF11 Proteine) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

Rabbit Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

  1. The OPG (zeige TNFSF11 Proteine) expression levels decreased while those of RANKL (zeige TNFSF11 Proteine) and RUNX2 (zeige RUNX2 Proteine) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

  2. Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (zeige TNFSF11 Proteine) mRNA expression.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaktionspartner

  1. Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.

Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Genbezeichner und Symbole assoziert mit TNFRSF11B

  • TNF receptor superfamily member 11b (TNFRSF11B)
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (Tnfrsf11b)
  • TNF receptor superfamily member 11B (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily member 11b S homeolog (tnfrsf11b.S)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • ocif Protein
  • opg Protein
  • tr1 Protein

Bezeichner auf Proteinebene für TNFRSF11B

osteoclastogenesis inhibitory factor , osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , Osteoprotegerin , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) , tumor necrosis factor receptor superfamily, member 11b , tumor necrosis factor receptor superfamily member 11B-like

GENE ID SPEZIES
4982 Homo sapiens
18383 Mus musculus
25341 Rattus norvegicus
464351 Pan troglodytes
523822 Bos taurus
100037695 Ovis aries
444716 Xenopus laevis
482025 Canis lupus familiaris
701850 Macaca mulatta
100399751 Callithrix jacchus
100433420 Pongo abelii
100465761 Ailuropoda melanoleuca
100599407 Nomascus leucogenys
100348133 Oryctolagus cuniculus
100049688 Sus scrofa
100860896 Capra hircus
100065885 Equus caballus
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