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The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase. Zusätzlich bieten wir Ihnen TRPM7 Kits (8) und TRPM7 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Mammalian Monoclonal TRPM7 Primary Antibody für ISt, IHC - ABIN1305027
Du, Xie, Zhang, Tsujikawa, Fusco, Silverman, Liang, Yue: TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. in Circulation research 2010
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Polyclonal TRPM7 Primary Antibody für IP, WB - ABIN540389
Runnels, Yue, Clapham: TRP-PLIK, a bifunctional protein with kinase and ion channel activities. in Science (New York, N.Y.) 2001
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Human Polyclonal TRPM7 Primary Antibody für IHC (p), WB - ABIN392614
Gavenis, Schumacher, Schneider, Eisfeld, Mollenhauer, Schmidt-Rohlfing: Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes. in Molecular and cellular biochemistry 2009
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Mouse (Murine) Polyclonal TRPM7 Primary Antibody für IHC (p), IHC - ABIN257037
Nadler, Hermosura, Inabe, Perraud, Zhu, Stokes, Kurosaki, Kinet, Penner, Scharenberg, Fleig: LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. in Nature 2001
tct may represent a novel as well as selective regulator of melanoblast development within the neural crest lineage.
Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
TRPM7 plays a role within sensory neurons in modulating neutrotransmitter release at central synapses, similar to the role proprosed for mammalian TRPM7 at peripheral synapses.
Trpm7 regulates exocrine pancreatic development via the Mg(2 (zeige MCOLN1 Antikörper)+)-sensitive Socs3a (zeige SOCS3 Antikörper) pathway.
This study showed that stanniocalcin 1 (stc1 (zeige STC1 Antikörper))modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 (zeige STC1 Antikörper) activity is blocked.
Mutation in trpm7 leads to defective skeletogenesis and kidney stone formation.
Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.
TRPM7 role in epithelial-mesenchymal transition, cell migration and invasion in prostate cancer cells
our results in vitro and in vivo have revealed that the downregulation of TRPM7 could reduce the BCa cell proliferation, trigger cell cycle arrest and apoptosis. In conclusion, downregulated TRPM7 could reduce the activity of bladder cancer cells and induce cell apoptosis via ERK1/2 pathway.
We have shown the contributions of TRPM7 in many physiological and pathophysiological processes, including hypoxia and ischaemia [review].
TRPM7 appears to play an important role in mechanosensing in mesenchymal stem cells. (Review)
Our results show that the activating TRPM7 channel may prevent AD-related Abeta (zeige APP Antikörper) neuropathology via modulating Ca(2 (zeige CA2 Antikörper)+)-regulated basal autophagy.
The results suggest that TRPM7 is required for proliferation, migration and invasion of ovarian cancer cells through regulating multiple signaling transduction pathways and the formation of focal adhesions.
The melastatin (zeige TRPM1 Antikörper)-like transient receptor potential cation channel (zeige TRPV1 Antikörper), subfamily M, member 7 (TRPM7), which is responsible for Mg(2 (zeige MUC7 Antikörper)+) entry, was studies and [Mg(2 (zeige MUC7 Antikörper)+)]i measured in cells stably expressing wildtype CFTR (zeige CFTR Antikörper), and two mutant proteins (DeltaF508-CFTR (zeige CFTR Antikörper) and G551D-CFTR (zeige CFTR Antikörper)). This study shows for the first time that [Mg(2 (zeige MUC7 Antikörper)+)]i is decreased in cells expressing DeltaF508-CFTR (zeige CFTR Antikörper) and G551D-CFTR (zeige CFTR Antikörper) mutated proteins.
Variability of the TRPM7 current density in human cardiomyocytes is related to the clinical history, being higher in atrial fibrillation and in ischemic cardiomyopathy.
our results show that TRPM7 is involved in PDAC cell invasion through regulation of Hsp90alpha (zeige HSP90AA2 Antikörper)/uPA (zeige PRAP1 Antikörper)/MMP-2 (zeige MMP2 Antikörper) proteolytic axis, confirming that this channel could be a promising biomarker and possibly a target for PDAC metastasis therapy.
Data show that activated TRPM7 activity contributes to the devastating migratory and invasive characteristics of glioblastoma (GBM) .
TRPM7 kinase activity regulates mast cell degranulation by changing its sensitivity to intracellular calcium.
TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions.
Inhibition of TRPM7 reduces calcium influx and accelerates the polarization of hippocampal neurons.
our results suggest the differential roles of TRPM7 in endochondral and intramembranous ossification.
TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice.
TRPM7 kinase is a novel player in Angiotensin II induced hypertension and vascular and target organ damage.
Immature intercellular junctions in Trpm7 knock-out mice might lead to a disruption of barrier function resulting in inflammation and hypersensitive bladder afferent nerves that may affect voiding behavior in vivo
By inhibiting TRPM7 and ANO1 (zeige ANO1 Antikörper) via opioid receptor signaling pathways.
Abolishing TRPM7 kinase activity does not impair its channel activity and kinase activity is not essential for regulation of mammalian Mg(2 (zeige MCOLN1 Antikörper)+) homeostasis.
results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation.
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.
transient receptor potential cation channel subfamily M member 7
, transient receptor potential melastatin 7
, transient receptor potential cation channel, subfamily M, member 7
, LTRPC ion channel family member 7
, channel-kinase 1
, long transient receptor potential channel 7
, transient receptor potential-phospholipase C-interacting kinase
, transient receptor potential M7
, transient receptor potential-related protein, ChaK