Transgelin Proteine (TAGLN)

The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Zusätzlich bieten wir Ihnen Transgelin Antikörper (220) und Transgelin Kits (28) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TAGLN 6876 Q01995
TAGLN 21345 P37804
TAGLN 25123 P31232
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Top Transgelin Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
Escherichia coli (E. coli) Human GST tag Transgelin (TAGLN) (AA 2-201), (full length) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$1,842.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$365.38
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,482.33
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,486.00
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,486.00
Details
Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$3,055.38
Details

TAGLN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,

Weitere Proteine zu Transgelin (TAGLN) Interaktionspartnern

Human Transgelin (TAGLN) Interaktionspartner

  1. High expression level of TAGLN is associated with prostate cancer.

  2. this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer

  3. During transition from the pluripotent stage towards the neural developmental stage, TAGLN is differentially expressed in bipolar patient derived cells compared to control derived cells.

  4. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.

  5. transgelin (TAGLN), a transforming growth factor beta (TGFbeta)-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells

  6. Smooth muscle 22 regulates the proliferation of aortic smooth muscle cells participates in the development of thoracic aortic dissection.

  7. regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 uptake

  8. Serum concentrations of CK-18 fragments and transgelin-2 correlate with the severity of NAFLD, but not with obesity.

  9. Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis

  10. activated AKT and JNK signaling pathways promote the overexpression of transgelin

  11. Cofilin-1 and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma

  12. Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.

  13. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.

  14. EZH2 regulates the chromatin structure at the TAGLN promoter through tri-methylation of H3K27, acting as an epigenetic integrator of IL-1beta and TGFbeta2 signaling.

  15. Transgelin may be an excellent diagnostic marker of Triple negative tumors and could be useful in stratification of patients

  16. Results indicate that miR-144 may regulate osteosarcoma cell proliferation and invasion by downregulating its target gene, transgelin protein (TAGLN), suggesting that miR-144 may be a potential therapeutic target for the treatment of osteosarcoma.

  17. TAGLN was highly expressed in NF1-deficient malignant peripheral nerve sheath tumors compared to NF1-deficient plexiform neurofibromas. Upregulation was caused by increased transcriptional expression. The TAGLN gene was hypomethylated in the MPNST cells.

  18. our data suggest that TAGLN may be a viable therapeutic target and a potential biomarker for predicting the prognosis of patients with lung adenocarcinoma.

  19. The expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression.

  20. They also antagonized the TGF-beta1 induced up-regulation of CTGF and transgelin.

Mouse (Murine) Transgelin (TAGLN) Interaktionspartner

  1. Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction.

  2. CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells.

  3. findings reveal for the first time that SM22 is expressed in the nucleus in addition to the cytoplasm of VSMCs to regulate the transcription of Nik and its downstream proinflammatory NF-kB signal pathways as a modulator of SRF during vascular inflammation

  4. The disruption of SM22alpha enhances PDGF-BB-induced GLUT4 translocation and glucose uptake by promoting actin dynamics and cortical actin polymeriza- tion.

  5. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.

  6. Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.

  7. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.

  8. SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling.

  9. TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.

  10. Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.

  11. SM22alpha-regulated molecular pathways contribute to vascular pathology.

  12. Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl ( tg ) mice

  13. Data show that formation of a Krupple-like factor KLF4, pELK-1, and histone de-acetylase 2 (HDAC2) multiprotein complex dependent on the SM22alpha G/C Repressor element.

  14. Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.

  15. We conclude that the de novo expression of SM22alpha in glomerular epithelial cells affects the course of crescentic glomerulonephritis.

  16. critical role for the Tsc1/Tsc2-mTORC1-S6K axis in the normal development of cardiovascular tissue

  17. SM22 downregulation can induce proinflammatory vascular smooth muscle cells through activation of ROS-mediated NF-kappaB pathways.

  18. The effects of dichloroacetate treatment on pulmonary artery smooth muscle cells and pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter are reported.

  19. loss of transgelin gene expression may be an important early event in tumor progression and a diagnostic marker for breast and colon cancer development.

  20. Data show that SM22alpha plays a role in contractility, possibly by affecting actin filament organisation

Transgelin (TAGLN) Protein Überblick

Protein Überblick

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Genbezeichner und Symbole assoziert mit Transgelin Proteine (TAGLN)

  • transgelin L homeolog (tagln.L)
  • transgelin (tagln)
  • transgelin (LOC732906)
  • transgelin (TAGLN)
  • transgelin (tagl)
  • transgelin (LOC100009332)
  • transgelin (Tagln)
  • MGC68550 Protein
  • MGC107855 Protein
  • Sm22 Protein
  • SM22A Protein
  • SMCC Protein
  • TAGLN1 Protein
  • WS3-10 Protein
  • Ws310 Protein
  • zgc:153186 Protein

Bezeichner auf Proteinebene für Transgelin Proteine (TAGLN)

transgelin , putative transgelin , 22 kDa actin-binding protein , SM22-alpha , smooth muscle protein 22-alpha , transgelin variant 2 , SM22 , Sm22alpha , actin-associated protein p27 , smooth muscle 22 protein , 25 kDa F-actin-binding protein , sm22 , sm22alpha-b

GENE ID SPEZIES
399014 Xenopus laevis
594967 Xenopus (Silurana) tropicalis
732906 Bombyx mori
100189993 Taeniopygia guttata
100528947 Ictalurus punctatus
6876 Homo sapiens
100009332 Oryctolagus cuniculus
21345 Mus musculus
25123 Rattus norvegicus
479424 Canis lupus familiaris
513463 Bos taurus
396490 Gallus gallus
397021 Sus scrofa
751758 Danio rerio
100728822 Cavia porcellus
Ausgewählte Anbieter für Transgelin Proteine (TAGLN)
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