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TRRAP encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. Zusätzlich bieten wir Ihnen Transformation/transcription Domain-Associated Protein Kits (2) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal TRRAP Primary Antibody für ChIP, IP - ABIN2668655
Szutorisz, Canzonetta, Georgiou, Chow, Tora, Dillon: Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. in Molecular and cellular biology 2005
Show all 2 Pubmed References
Data suggest that ubiquitin thioesterase 7 (HAUSP (zeige USP7 Antikörper)) may act as an oncogenic protein that can modulate c-MYC (zeige MYC Antikörper) protein expression via transformation-transcription domain-associated protein (TRRAP).
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (zeige CREBBP Antikörper), CBFA2T3 (zeige CBFA2T3 Antikörper), AMOTL1 (zeige AMOTL1 Antikörper), FAT4 (zeige FAT4 Antikörper), FBXO11 (zeige FBXO11 Antikörper), PLA2G4D (zeige PLA2G4D Antikörper), TRRAP and USH2A (zeige USH2A Antikörper).
MYC associates with STAGA through extended interactions of the TAD with both TRRAP and GCN5.
Findings establish Trrap as a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs (zeige NR2E3 Antikörper).
TRRAP is targeted for destruction in a cell cycle-dependent fashion.
The over-expression of TRA1 (zeige HSP90B1 Antikörper) in hepatocirrhosis and hepatocellular carcinoma is correlated with the formation and development of HCC (zeige FAM126A Antikörper).
TRRAP harbors a recurrent mutation that clustered in one position (p. Ser722Phe) in 6 out of 167 melanoma samples (approx. 4%). The nature, pattern and functional evaluation of the TRRAP recurrent mutation suggest that TRRAP functions as an oncogene (zeige RAB1A Antikörper).
knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured brain tumor-initiating cells, sensitized the cells to apoptotic stimuli, and negatively affected cell cycle progression.
TRRAP binding and the recruitment of histone H3 (zeige HIST3H3 Antikörper) and H4 acetyltransferase activities are required for the transactivation of a silent TERT (zeige TERT Antikörper) gene in exponentially growing human fibroblasts by c-Myc (zeige MYC Antikörper) or N-Myc protein (zeige MYCN Antikörper).
Data suggest a model in which p53 (zeige TP53 Antikörper) directly recruits a TRRAP/acetyltransferase complex to the mdm2 (zeige MDM2 Antikörper) gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor (zeige TP53 Antikörper) to regulate gene expression.
TRRAP deficiency impairs B-cell development but does not directly affect class switch recombination (CSR (zeige SCARA3 Antikörper). Instead, cells induced to proliferate undergo apoptosis. Our findings demonstrate a central and general role of TRRAP in cell proliferation.
expression profiles of Trrap-responsive genes, using cDNA microarray in mitotic cells
Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (zeige BUB3 Antikörper) proteins Mad1 (zeige MXD1 Antikörper) and Mad2 (zeige MXI1 Antikörper).
HAT (zeige HAT Antikörper) cofactor Trrap and Tip60 (zeige KAT5 Antikörper) HAT (zeige HAT Antikörper) bind to the chromatin surrounding sites of DNA double-strand breaks (DSBs). Cells may use the same basic mechanism involving HAT (zeige HAT Antikörper) complexes to regulate distinct cellular processes, such as transcription and DNA repair.
Fe65 (zeige APBB1 Antikörper) and its interaction with APP (zeige APP Antikörper) play an important role in the response to DNA damage by assisting the recruitment
this study has identified a critical role for Trrap in the mechanism that maintains hematopoietic stem cells and hematopoietic system, and underscores the importance of Trrap and histone modifications in tissue homeostasis.
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transformation/transcription domain-associated protein
, transformation/transcription domain-associated protein-like
, 350/400 kDa PCAF-associated factor
, tra1 homolog
, transactivation/transformation-domain associated protein