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TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Zusätzlich bieten wir Ihnen TIGIT Antikörper (59) und TIGIT Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Natural killer cells and cytotoxic T cells express both TIGIT and DNAM-1 (zeige CD226 Proteine) receptors, and in certain cases their effector functions are dictated by TIGIT or DNAM-1 (zeige CD226 Proteine) signaling. Agonist and antagonist antibodies targeting either TIGIT or DNAM-1 (zeige CD226 Proteine) present many therapeutic options for diseases spanning from cancer to auto-immunity. (Review)
TIGIT contributes to functional T-cell impairment and associates with poor clinical outcome in acute myelogenous leukemia. The study suggests that blockade of TIGIT to restore T-cell function and antitumor immunity may represent a novel effective leukemia therapeutic.
Blimp-1 (zeige PRDM1 Proteine) binds to the promoters of PD-1 (zeige PDCD1 Proteine) and TIGIT and positively regulates their expression in patients with acute myeloid leukemia (zeige BCL11A Proteine).
Data show that gastric cancer cells inhibit T-cell metabolism through CD155 (zeige PVR Proteine)/TIGIT signaling.
Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells.
Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 (zeige PVRL2 Proteine) by TIGIT.
TIGIT is a powerful negative regulator of CD4 (zeige CD4 Proteine)(+) T cells in systemic lupus erythematosus.
TIGIT signaling in NK cells after MDSC coculture led to a decrease in the phosphorylation of ZAP70/Syk and ERK1/2.
energetic basis for the TIGIT/nectin-2 (zeige PVRL2 Proteine) interaction and revealed that an "aromatic key" of nectin-2 (zeige PVRL2 Proteine) is critical for this interaction, whereas variations in the lock were tolerated.
TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.
study provides evidence that TIGIT expression by Th cells and its interaction with CD155 (zeige PVR Proteine) enhances Th2 responses, and blockade of TIGIT is therapeutic for experimental allergic airway inflammation
TIGIT negatively regulates inflammation by altering macrophage phenotype.
TIGIT signaling in Tregs directs their phenotype. It suppresses antitumor immunity via Tregs and not CD8 (zeige CD8A Proteine)+ T cells. TIGIT+ Tregs upregulated TIM-3 (zeige HAVCR2 Proteine) expression in tumor tissue. TIM-3 (zeige HAVCR2 Proteine) and TIGIT synergized to suppress antitumor immune responses.
TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK-hepatocyte crosstalk.
Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (zeige CD226 Proteine) function when disrupting its homodimerization.
TIGIT/PVR (zeige PVRL2 Proteine) ligation signaling mediates suppression of IFN-gamma (zeige IFNG Proteine) production via the NF-kappaB (zeige NFKB1 Proteine) pathway.
expressed on a Treg cell subset that selectively suppresses Th1 (zeige HAND1 Proteine) and Th17 cells but not Th2 cells
found that TIGIT was up-regulated selectively on NK cells and protected against liver injury in an acute adenovirus infection model in both an NK cell- and Kupffer cell-dependent manner
findings show that TIGIT is expressed by NK cells, that it interacts specifically with PVR (zeige PVRL2 Proteine) and possibly with an additional unknown ligand found on PBMCs and that these interactions lead to the inhibition of NK-cell activities
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity\; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
T-cell immunoreceptor with Ig and ITIM domains
, V-set and immunoglobulin domain containing 9
, V-set and immunoglobulin domain-containing protein 9
, V-set and transmembrane domain containing 3
, V-set and transmembrane domain-containing protein 3
, Washington University cell adhesion molecule