Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 Proteine (SLC7A11)

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Zusätzlich bieten wir Ihnen SLC7A11 Antikörper (103) und SLC7A11 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC7A11 23657 Q9UPY5
SLC7A11 310392  
SLC7A11 26570 Q9WTR6
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
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Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$544.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$525.90
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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SLC7A11 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Rat (Rattus)
Mouse (Murine)

Weitere Proteine zu Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Interaktionspartnern

Human Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Interaktionspartner

  1. the over-expression of SLC7A11, or supplementation with sufficiently cystine, or treatment with N-acetylcysteine significantly decreased P-gp expression and activity. It was suggested that ROS and SLC7A11/cystine were the two relevant factors responsible for the expression and function of P-gp, and that SLC7A11 might be a potential target modulating ADR resistance.

  2. In some breast cancer cells, xCT antiporter expression is upregulated through the antioxidant transcription factor Nrf2 and contributes to their requirement for glucose as a carbon source.

  3. accumulated mutant-p53 protein suppresses the expression of SLC7A11, a component of the cystine/glutamate antiporter, system xC(-), through binding to the master antioxidant transcription factor NRF2.

  4. System xC(-)-mediated TrkA activation therefore presents a promising target for therapeutic intervention in cancer pain treatment.

  5. High expression of cystine-glutamate antiporter SLC7A11 is associated with advanced pathological stages of liver carcinoma. SLC7A11 overexpression is a novel biomarker and a potential unfavorable prognostic factor as well as a potential therapeutic target for liver carcinoma.

  6. the level of antisense SLC7A11 was markedly reduced in epithelial ovarian cancer tissues and cell lines compared with those of normal control; reduction of antisense SLC7A11 level prompted ovarian cancer cell migration mainly by suppressing the expression of SLC7A11

  7. CD44v9 in tumor specimens has potential as a novel indicator for identifying a cisplatin-chemoresistant population among urothelial cancer patients. CD44v8-10 contributes to reactive oxygen species defenses, which are involved in chemoresistance, by promoting the function of xCT, which adjusts the synthesis of glutathione.

  8. Oncogenic PIK3CA alters methionine and cysteine utilization, partly by inhibiting xCT to contribute to the methionine dependency phenotype in human breast cancer cells.

  9. these observations suggest that SLC7A11 may be a vital biomarker for the diagnosis and prognosis in human laryngeal squamous cell carcinoma (LSCC) and targeting SLC7A11 appears to be a potentially significant method for LSCC treatment.

  10. Aberrant neuronal or neuroendocrine system may be involved in the suppressed reproductive performance in xCT deficient male mice.

  11. overexpression of SLC7A11 in the context of glioblastoma multiforme may contribute to tumor progression.

  12. miR-375 served as a tumor suppressor via regulating SLC7A11.

  13. As targets of oncogenes with intrinsic tyrosine kinase activity, STAT3 and STAT5 become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT expression. (Review)

  14. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb) through TLR2/Akt- and p38-dependent signaling pathway.

  15. Genetic and pharmacological inhibition of xCT potentiated the cytotoxic effects of aspirin plus sorafenib; this effect was diminished by xCT overexpression. Low-dose aspirin plus sorafenib enhanced the cytotoxicity of cisplatin in resistant HNC cells through xCT inhibition and oxidant and DNA damage.

  16. MUC1-C binds directly with CD44v and in turn promotes stability of xCT in the cell membrane

  17. simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR and SLC7A11. Moreover, p53(4KR) is still capable of inducing the p53-Mdm2 feedback loop, but p53-dependent ferroptotic responses are markedly abrogated

  18. ARF inhibits tumor growth by suppressing the ability of NRF2 to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate antiporter that regulates reactive oxygen species (ROS)-induced ferroptosis.

  19. Mechanistically, CD44v interacts with and stabilizes xCT and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.

  20. ATF4 expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate antiporter xCT

SLC7A11 Protein Überblick

Protein Überblick

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Genbezeichner und Symbole assoziert mit SLC7A11

  • solute carrier family 7 member 11 (SLC7A11)
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11)
  • solute carrier family 7 member 11 (Slc7a11)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11)
  • 9930009M05Rik Protein
  • AI451155 Protein
  • CCBR1 Protein
  • DKFZp468E122 Protein
  • SLC7A11 Protein
  • sut Protein
  • xCT Protein

Bezeichner auf Proteinebene für SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 , cystine/glutamate transporter , solute carrier family 7, member 11 , Cystine/glutamate transporter , cystine/glutamate transporter-like , solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 , amino acid transport system xc- , calcium channel blocker resistance protein CCBR1 , solute carrier family 7 member 11 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 , cysteine/glutamate transporter , sodium independent anionic amino acid transport system

GENE ID SPEZIES
428731 Gallus gallus
471310 Pan troglodytes
524078 Bos taurus
696516 Macaca mulatta
100027770 Monodelphis domestica
100049683 Sus scrofa
100091177 Ornithorhynchus anatinus
100172659 Pongo abelii
100386974 Callithrix jacchus
100581045 Nomascus leucogenys
23657 Homo sapiens
310392 Rattus norvegicus
483821 Canis lupus familiaris
26570 Mus musculus
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