SLC7A11 Protein

Produktnummer ABIN7491739

Produktdetails

Target: SLC7A11 (Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11))

Protein-Typ: Synthetic

Spezies: Human

Quelle: HEK-293 Cells

Verwendungszweck: Human SLC7A11 full length protein-synthetic nanodisc

Produktmerkmale: Full Length Transmembrane Proteins (synthetic Nanodisc)

Anwendungsinformationen

Applikationshinweise:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Kommentare:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: SLC7A11 (Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11))

Andere Bezeichnung: SLC7A11 (SLC7A11 Produkte)

Synonyme: SLC7A11 Protein, DKFZp468E122 Protein, CCBR1 Protein, xCT Protein, 9930009M05Rik Protein, AI451155 Protein, sut Protein, solute carrier family 7 member 11 Protein, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 Protein, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Protein, SLC7A11 Protein, Slc7a11 Protein

Hintergrund: CCBR1, xCT
Description: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

Molekulargewicht: The human full length SLC7A11 protein has a MW of 55.4 kDa

UniProt: Q9UPY5