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The protein encoded by SIRPG is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily.
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SIRPgamma in complex with FabOX117 forms a dimer in the crystal. Binding to the Fab (zeige FANCB Proteine) fixes the position of domain 1 relative to domains 2/3 exposing a surface which favours formation of a homotypic dimer.
The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA (zeige SIRPA Proteine) and SIRPG.
a novel member of the signal regulatory protein (SIRP (zeige SIRPA Proteine)) family- with unique characteristics from both alpha and beta genes- termed SIRPgamma
CD47 (zeige CD47 Proteine) is enriched at endothelial junctions, and its interaction with SIRPgamma is required for human T-cell transendothelial migration
tumor necrosis factor (zeige TNF Proteine) receptor superfamily, member 14 (TNFRSF14 (zeige TNFRSF14 Proteine)) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus.
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
CD172 antigen-like family member B
, CD172g antigen
, SIRP beta 2
, signal-regulatory protein beta 2
, signal-regulatory protein beta-2
, signal-regulatory protein gamma
, NSFL1 (p97) cofactor (p47)-like
, signal-regulatory protein beta-2-like