Sema Domain, Seven thrombospondin Repeats (Type 1 and Type 1-Like), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 5A Proteine (SEMA5A)

Zebrafish Sema Domain, Seven thrombospondin Repeats (Type 1 and Type 1-Like), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 5A (SEMA5A) Interaktionspartner

1. Sema5A is a bifunctional axon guidance cue for vertebrate motor axons in vivo. The TSR (zeige CFL1 Proteine) domain promotes growth of developing motor axons into the ventral myotome whereas the sema (zeige SEMA3B Proteine) domain mediates repulsion

Human Sema Domain, Seven thrombospondin Repeats (Type 1 and Type 1-Like), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 5A (SEMA5A) Interaktionspartner

1. SEMA5A gene is associated with hippocampal volume, and their interaction is associated with reasoning ability.

2. De novo translocation t(5;22)(p15.3;q11.21) associated with a partial deletion of SEMA5A identified in a patient with ASD (zeige ARSD Proteine).

3. data demonstrated that elevated serum Semaphorin5A in systemic lupus erythematosus patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 (zeige ADAM17 Proteine) might be involved in the release of secreted Sema5A

4. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described.

5. The Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development.

6. Using human gastric cancer cell lines, found semaphorin 5A significantly promoted invasive & metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell.

7. Results suggest that a bioactive, secreted form of Sema5A-ECD (zeige SHFM1 Proteine) has an intriguing and potentially important role in its ability to enhance pancreatic tumour invasiveness, angiogenesis and micrometastases.

8. Data show that Semaphorin 5A (Sema5A) and plexin-B3 (zeige PLXNB3 Proteine) inhibit glioma cell invasion through Rac1 inactivation.

9. The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC.

10. Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha.

Mouse (Murine) Sema Domain, Seven thrombospondin Repeats (Type 1 and Type 1-Like), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 5A (SEMA5A) Interaktionspartner

1. Mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells.

2. The results of this study concluded that the Sema5a mice do not meet the behavioral criteria for a mouse model of autism.

3. Sema5A and Sema5B (zeige SEMA5B Proteine) inhibit retinal neurite outgrowth through PlexinA1 (zeige PLXNA1 Proteine) and PlexinA3 (zeige PLXNA3 Proteine) receptors both in vitro and in vivo.

4. Data reveal that Sema5A is a novel proangiogenic molecule, inducing endothelial cell proliferation and migration and inhibiting apoptosis.

5. development of some CNS nerves requires inhibitory sheaths to maintain integrity, this is accomplished using molecules such as Sema5A that exhibit conserved inhibitory responses in the presence of impinging signals from multiple guidance molecules.

6. Plexin-B3 (zeige PLXNB3 Proteine) is a functional receptor for semaphorin 5A

7. Semaphorin 5A (Sema5A) is a bifunctional guidance cue exerting both attractive and inhibitory effects on developing axons of the fasciculus retroflexus, a diencephalon fiber tract associated with limbic function.

8. A role of Sema5A in the remodeling of the cranial blood vessels was shown.