Sec61 alpha 1 Subunit (S. Cerevisiae) Proteine (SEC61A1)

The protein encoded by SEC61A1 belongs to the SECY/SEC61- alpha family. Zusätzlich bieten wir Ihnen Sec61 alpha 1 Subunit (S. Cerevisiae) Antikörper (50) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SEC61A1 29927 P61619
SEC61A1 53421 P61620
Ratte SEC61A1 SEC61A1 80843 P61621
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
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SEC61A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Interaktionspartnern

Human Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Interaktionspartner

  1. Shows that inhibition of Sec61 by mycolactone drives rapid and broad translational reprogramming of a subset of genes involved in stress responses that is initially protective but ultimately leads to cell death

  2. Unpicking the central dogma of molecular biology step-by-step identifies the Sec61 translocon as the target of anti-inflammatory activity of mycolactone, explaining why production of Sec61-dependent proteins (secretory, ER resident and membrane bound) is lost even though transcription and translation are unaffected.

  3. The direct contribution of Sec61 to antigen cross-presentation, endosome-to-cytosol export, and endoplasmic reticulum-to-cytosol export.

  4. The authors propose that the Sec61-IRE1alpha (zeige ERN1 Proteine) complex defines the extent of IRE1alpha (zeige ERN1 Proteine) activity and may determine cell fate decisions during endoplasmic reticulum stress conditions.

  5. EPO (zeige EPO Proteine) (7q22) and SEC-61(7p11) emerged as new candidate genes susceptible to genetic losses with 57.7% deletions identified in regions on chromosome 7.

  6. Tomography densities at subnanometer resolution revealed an intricate network of interactions between the ribosome, Sec61 and accessory translocon components that assist in protein transport, membrane insertion and maturation

  7. The discovery of export-specific sec61 mutants and of mammalian ER-associated degradation (ERAD) substrates whose export is dependent on the 19S regulatory particle suggest that dismissal of a role of Sec61 in export may have been premature.

  8. the effect of mycolactone on transmembrane protein biogenesis depends on how the nascent chain initially engages the Sec61 complex.

  9. data provide definitive genetic evidence that Sec61 is the host receptor mediating the diverse immunomodulatory effects of mycolactone and identify Sec61 as a novel regulator of immune cell functions.

  10. findings provide a mechanism by which mutations in SEC61A1 lead to an autosomal-dominant syndromic form of progressive chronic kidney disease; we highlight protein translocation defects across the endoplasmic reticulum membrane, the principal role of the SEC61 complex, as a contributory pathogenic mechanism for autosomal-dominant tubulo-interstitial kidney disease

Mouse (Murine) Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Interaktionspartner

  1. The direct contribution of Sec61 to antigen cross-presentation, endosome-to-cytosol export, and endoplasmic reticulum-to-cytosol export.

  2. Interaction of ribosomes and Sec62 (zeige TLOC1 Proteine) with the core Sec61 translocon is mutually exclusive.

  3. SEC61A1 gene silencing inhibits co- and post-translational transport of presecretory proteins into endoplasmic reticulum.

  4. Diabetes can bemapped to a point mutation in the Sec61a1 gene that encodes a His to Tyr (zeige TYR Proteine) substitution at amino acid 344.

Zebrafish Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Interaktionspartner

  1. A screen for mutations that affect habenular laterality led to the identification of the sec61a-like 1(sec61al1) gene.

Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.

Genbezeichner und Symbole assoziert mit SEC61A1

  • Sec61 translocon alpha 1 subunit (SEC61A1)
  • Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1)
  • Sec61 translocon alpha 1 subunit (Sec61a1)
  • Sec61 translocon alpha 1 subunit S homeolog (sec61a1.S)
  • Sec61 translocon alpha 1 subunit (sec61a1)
  • preprotein translocase subunit SecY (HVO_RS16965)
  • Sec61 alpha 1 subunit (Sec61a1)
  • translocon subunit (SEC61)
  • translocon alpha subunit Sec61 (sec61)
  • AA408394 Protein
  • AA410007 Protein
  • chunp6898 Protein
  • fb62c11 Protein
  • HSEC61 Protein
  • sec61 Protein
  • sec61a Protein
  • SEC61A1 Protein
  • sec61al1 Protein
  • sec61alpha Protein
  • secY1 Protein
  • wu:fb62c11 Protein

Bezeichner auf Proteinebene für SEC61A1

Sec61 alpha-1 , protein transport protein SEC61 alpha subunit , protein transport protein Sec61 subunit alpha , protein transport protein Sec61 subunit alpha isoform 1 , sec61 homolog , SEC61, alpha subunit , sec61 alpha-1 , transport protein sec61 alpha subunit , Sec61 alpha subunit homolog , sec61 homologue , Sec61 alpha 1 subunit (S. cerevisiae) , Sec61 alpha form 1 , transport protein Sec61 alpha subunit , Protein transport protein Sec61 subunit alpha , protein transport protein Sec61 subunit alpha-like , Sec61 alpha like 1 , protein transport protein Sec61 subunit alpha-like 1 , hypothetical protein

GENE ID SPEZIES
29927 Homo sapiens
53421 Mus musculus
80843 Rattus norvegicus
379936 Xenopus laevis
404006 Canis lupus familiaris
416023 Gallus gallus
448033 Xenopus (Silurana) tropicalis
460669 Pan troglodytes
505064 Bos taurus
8925650 Haloferax volcanii DS2
100144911 Acyrthosiphon pisum
100155306 Sus scrofa
100173741 Pongo abelii
100413259 Callithrix jacchus
100603743 Nomascus leucogenys
192298 Danio rerio
3647462 Candida albicans SC5314
2541037 Schizosaccharomyces pombe 972h-
100723492 Cavia porcellus
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