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Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Zusätzlich bieten wir Ihnen SUMO1 Activating Enzyme Subunit 2 Antikörper (77) und SUMO1 Activating Enzyme Subunit 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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We propose that disturbance of the SUMOylation pathway, mediated by pathogenic variants in UBA2, is a novel mechanism for aplasia cutis congenita and other phenotypic abnormalities.
Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus.
Data indicate the role of anti-SUMO activating enzyme SAE1 (zeige SAE1 ELISA Kits) and SAE2 antibody as marker of dermatomyositis.
Data show that the SAE2 subunit of the small ubiquitin-like modifier (SUMO (zeige SUMO1 ELISA Kits)) E1 is autoSUMOylated at residue Lys (zeige LYZ ELISA Kits)-236, and SUMOylation was catalyzed by Ubc9 (zeige UBE2I ELISA Kits) at several additional Lys (zeige LYZ ELISA Kits) residues surrounding the catalytic Cys (zeige DNAJC5 ELISA Kits)-173 of SAE2.
loss of SAE1 (zeige SAE1 ELISA Kits)/2 activity drives synthetic lethality with Myc (zeige MYC ELISA Kits); inactivation of SAE2 leads to mitotic catastrophe and cell death upon Myc (zeige MYC ELISA Kits) hyperactivation; findings in Myc (zeige MYC ELISA Kits)-high breast cancers suggest low tumor SAE1 (zeige SAE1 ELISA Kits) and SAE2 correlates metastasis-free survival
The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.
structures of heterodimeric Sae1 (zeige SAE1 ELISA Kits)/Sae2-Mg.ATP and Sae1 (zeige SAE1 ELISA Kits)/Sae2-SUMO-1 (zeige SUMO1 ELISA Kits)-Mg.ATP complexes
UBA2 stabilizes APOBEC3G by preventing ubiquitin chain elongation and proteasome-mediated proteolysis.
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999
SUMO1 activating enzyme subunit 2
, SUMO-1 activating enzyme subunit 2
, SUMO-activating enzyme subunit 2
, UBA2, ubiquitin-activating enzyme E1 homolog
, anthracycline-associated resistance ARX
, ubiquitin-like 1-activating enzyme E1B
, Sumo-1 activating enzyme subunit 2
, ubiquitin-like 1 (sentrin) activating enzyme E1B
, ubiquitin-like 1 (sentrin) activating enzyme subunit 2
, SUMO-activating enzyme subunit 2-A
, SUMO-activating enzyme subunit 2-B
, ubiquitin-like 1-activating enzyme E1B-A
, ubiquitin-like 1-activating enzyme E1B-B
, SUMO1 activating enzyme subunit 2b