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SH3GL1 encodes a member of the endophilin family of Src homology 3 domain-containing proteins. Zusätzlich bieten wir Ihnen SH3GL1 Antikörper (100) und SH3GL1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Study observed elevated EA2 (zeige CACNA1A Proteine) gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 (zeige CACNA1A Proteine) gene expression negatively correlated with adiponectin and chemerin (zeige RARRES2 Proteine) in visceral adipose tissue, and positively correlated with TNF-alpha (zeige TNF Proteine) in subcutaneous adipose tissue. EA2 (zeige CACNA1A Proteine) gene expression was significantly downregulated during differentiation of preadipocytes in vitro.
Our study provides novel evidence of Endo II function in HER2 (zeige ERBB2 Proteine)+ cancer cell motility and trafficking of HER2 (zeige ERBB2 Proteine) that relates to effective treatments with trastuzumab or T-DM1 (zeige DMPK Proteine). Thus, differential expression of Endo II may relate to sensitivity or resistance to trastuzumab-based therapies for HER2 (zeige ERBB2 Proteine)+ cancers
Expression level of SH3GL1 was widely upregulated in human OS tissues, and their overexpression was significantly correlated with more aggressive clinicopathological features.
Endophilin-A2 was identified as a novel molecule regulating macrophage-derived foam cell formation by mechanisms attributable to clathrin-mediated endocytosis and beyond clathrin-mediated endocytosis
inhibition of SH3GL1 reverses multidrug resistance through declining P-glycoprotein expression via the EGFR (zeige EGFR Proteine)/ERK (zeige EPHB2 Proteine)/AP-1 (zeige FOSB Proteine) pathway.
results establish a novel function of endoA2 in clathrin-independent endocytosis
these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma.
MIR218 functions as a tumor suppressor by regulating SH3GL1 expression in medulloblastoma cancer cells.
SH3GL1 may be involved in the oncogenic process of gliomas and effectively elicit an autologous antibody response in low-grade gliomas.
Two endophilin A2 mutants, E264A and E264R, have different effects on how endophilin interacts with other proteins, such as dynamin (zeige DNM1 Proteine) or beta1-adrenergic receptors.
This study provides a new mechanism by which endophilin A2 regulates ClC-3 (zeige CLCN3 Proteine) channel activity, and sheds light on how ClC-3 (zeige CLCN3 Proteine) is transported to cell membranes to play its critical role as a chloride channel (zeige CLCA1 Proteine) in VSMCs function
Mutation in the FAK (zeige PTK2 Proteine) gene disrupted the function of FAK (zeige PTK2 Proteine) scaffolding to mediate endophilin A2 phosphorylation at Tyr (zeige TYR Proteine)-315 by Src (zeige SRC Proteine), leading to the decreased surface expression of MT1-MMP (zeige MMP14 Proteine).
these results demonstrate that MNSFbeta/endophilin II inhibits the signal pathway upstream of IKK activation, but not downstream of TLR2 signaling.
Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin (zeige ADD2 Proteine), septin 2 (zeige SEPT2 Proteine), and sh3p8 as putative paranodal proteins.
Mll (zeige MLL Proteine)(Een/+) chimeric mice developed leukaemia displaying enlarged livers, spleens, thymuses and lymph nodes owing to infiltration of Mll (zeige MLL Proteine)(Een/+)-expressing leukemic cells
post-translational modification of endophilin II by MNSFbeta (zeige FAU Proteine) might be implicated in phagocytosis by macrophages.
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
EEN fusion partner of MLL
, SH3 domain protein 2B
, SH3 domain-containing GRB2-like protein 1
, SH3-containing Grb-2-like 1 protein
, extra 11-19 leukemia fusion
, extra eleven-nineteen leukemia fusion gene protein
, endophilin II
, SH3-domain GRB2-like 1
, SH3 domain-containing GRB2-like protein 2
, SH3-domain GRB2-like 1a
, SH3-domain GRB2-like 1b