SH3-Domain GRB2-Like 1 Proteine (SH3GL1)

SH3GL1 encodes a member of the endophilin family of Src homology 3 domain-containing proteins. Zusätzlich bieten wir Ihnen SH3GL1 Antikörper (102) und SH3GL1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SH3GL1 6455 Q99961
SH3GL1 20405 Q62419
SH3GL1 81922 O35964
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Top SH3GL1 Proteine auf

Showing 7 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

SH3GL1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu SH3-Domain GRB2-Like 1 (SH3GL1) Interaktionspartnern

Human SH3-Domain GRB2-Like 1 (SH3GL1) Interaktionspartner

  1. Study observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-alpha in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro.

  2. Our study provides novel evidence of Endo II function in HER2+ cancer cell motility and trafficking of HER2 that relates to effective treatments with trastuzumab or T-DM1. Thus, differential expression of Endo II may relate to sensitivity or resistance to trastuzumab-based therapies for HER2+ cancers

  3. Expression level of SH3GL1 was widely upregulated in human OS tissues, and their overexpression was significantly correlated with more aggressive clinicopathological features.

  4. Endophilin-A2 was identified as a novel molecule regulating macrophage-derived foam cell formation by mechanisms attributable to clathrin-mediated endocytosis and beyond clathrin-mediated endocytosis

  5. inhibition of SH3GL1 reverses multidrug resistance through declining P-glycoprotein expression via the EGFR/ERK/AP-1 pathway.

  6. Endo II expression was highest in triple-negative breast cancers tumors compared with other subtypes, and at the level of gene expression, high Endo II was associated with reduced relapse-free survival in patients with basal-like breast cancers.

  7. results establish a novel function of endoA2 in clathrin-independent endocytosis

  8. these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma.

  9. MIR218 functions as a tumor suppressor by regulating SH3GL1 expression in medulloblastoma cancer cells.

  10. SH3GL1 may be involved in the oncogenic process of gliomas and effectively elicit an autologous antibody response in low-grade gliomas.

  11. Two endophilin A2 mutants, E264A and E264R, have different effects on how endophilin interacts with other proteins, such as dynamin or beta1-adrenergic receptors.

  12. Idiopathic scoliosis is a multifactorial genetic disease and SH3GL1 may be one of the pathogenic genes for this disease.

  13. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  14. SH3GL1 is possibly one of the disease associated genes of adolescent idiopathic scoliosis.

  15. new mechanism for MLL-EEN-mediated leukemogenesis in which MLL-EEN interferes with the Ras-suppressing activities of EBP through direct interaction.

  16. EEN part plays an essential role in leukemogenesis caused by MLL-EEN.

  17. Our results suggest that distinct subcellular localization of the endophilin A family members probably underpins their diverse cellular functions and indicates a role for EEN/EA2 in the cell cycle.

  18. findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain

Mouse (Murine) SH3-Domain GRB2-Like 1 (SH3GL1) Interaktionspartner

  1. This study provides a new mechanism by which endophilin A2 regulates ClC-3 channel activity, and sheds light on how ClC-3 is transported to cell membranes to play its critical role as a chloride channel in VSMCs function

  2. Mutation in the FAK gene disrupted the function of FAK scaffolding to mediate endophilin A2 phosphorylation at Tyr-315 by Src, leading to the decreased surface expression of MT1-MMP.

  3. these results demonstrate that MNSFbeta/endophilin II inhibits the signal pathway upstream of IKK activation, but not downstream of TLR2 signaling.

  4. Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin, septin 2, and sh3p8 as putative paranodal proteins.

  5. Mll(Een/+) chimeric mice developed leukaemia displaying enlarged livers, spleens, thymuses and lymph nodes owing to infiltration of Mll(Een/+)-expressing leukemic cells

  6. post-translational modification of endophilin II by MNSFbeta might be implicated in phagocytosis by macrophages.

SH3GL1 Protein Überblick

Protein Überblick

This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit SH3GL1

  • SH3 domain containing GRB2 like 1, endophilin A2 (SH3GL1)
  • SH3-domain GRB2-like 1 (Sh3gl1)
  • SH3 domain containing GRB2 like 1, endophilin A2 (Sh3gl1)
  • SH3-domain GRB2-like 1b (sh3gl1b)
  • SH3-domain GRB2-like 1 L homeolog (sh3gl1.L)
  • SH3-domain GRB2-like 1 (sh3gl1)
  • SH3-domain GRB2-like 1a (sh3gl1a)
  • C77078 Protein
  • cb831 Protein
  • CNSA1 Protein
  • EEN Protein
  • MGC78966 Protein
  • MGC130739 Protein
  • Sh3d2b Protein
  • sh3gl1 Protein
  • sh3gl1b Protein
  • SH3P8 Protein
  • wu:fd12b05 Protein
  • wu:fy33c10 Protein
  • zgc:56637 Protein

Bezeichner auf Proteinebene für SH3GL1

EEN fusion partner of MLL , SH3 domain protein 2B , SH3 domain-containing GRB2-like protein 1 , SH3-containing Grb-2-like 1 protein , endophilin-2 , endophilin-A2 , extra 11-19 leukemia fusion , extra eleven-nineteen leukemia fusion gene protein , endophilin II , SH3-domain GRB2-like 1 , eena , SH3 domain-containing GRB2-like protein 2 , SH3-domain GRB2-like 1a , SH3-domain GRB2-like 1b , eenb

6455 Homo sapiens
20405 Mus musculus
81922 Rattus norvegicus
378838 Danio rerio
395202 Gallus gallus
432228 Xenopus laevis
512719 Bos taurus
619364 Xenopus (Silurana) tropicalis
485039 Canis lupus familiaris
100735863 Cavia porcellus
100005753 Danio rerio
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