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PCBD1 encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. Zusätzlich bieten wir Ihnen PCBD1 Antikörper (51) und und viele weitere Produktgruppen zu diesem Protein an.
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DCoH acts as a cofactor for HNF1 that stabilizes the dimeric HNF1 complex.
HNF1alpha (zeige HNF1A Proteine) binding kinetics may distinguish regulation by DCoH2 (zeige PCBD2 Proteine), under thermodynamic control, from regulation by DCoH, under kinetic control
We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A (zeige HNF1A Proteine)-diabetes.
Coactivator of the HNFB1 (HNF1 homeobox B (zeige HNF1B Proteine))-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2 (zeige FXYD2 Proteine)) transcription in the distal convoluted tubule
Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha (zeige HNF1A Proteine).
variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2 (zeige HNF1B Proteine)) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function
Data reveal DCoH/HNF-1 alpha (zeige HNF1A Proteine) expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase (zeige TYR Proteine), the key enzyme for pigmentation, as a new transcriptional target.
Albumin (zeige ALB Proteine) colocalized together with its transcription factor PCD/DCoH/HNF-1alpha (zeige HNF1A Proteine) in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium.
Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH
This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1).
, pterin-4-alpha-carbinolamine dehydratase
, 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
, 4-alpha-hydroxy-tetrahydropterin dehydratase
, dimerization cofactor of HNF1
, dimerization cofactor of hepatocyte nuclear factor 1-alpha
, dimerization cofactor of hepatocyte nuclear factor-1-alpha
, phenylalanine hydroxylase-stimulating protein
, pterin carbinolamine dehydratase
, 6-pyruvoyl-tetrahydropterin synthase
, pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
, dimerizing cofactor for HNF1
, pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1