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The protein encoded by PTPRA is a member of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen PTPRA Proteine (13) und PTPRA Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 111 products:
Human Monoclonal PTPRA Primary Antibody für IF, IP - ABIN967914
Sap, DEustachio, Givol, Schlessinger: Cloning and expression of a widely expressed receptor tyrosine phosphatase. in Proceedings of the National Academy of Sciences of the United States of America 1990
Show all 3 Pubmed References
Bat Polyclonal PTPRA Primary Antibody für IHC (p) - ABIN271250
Wu, Kao, Li, Chi, Lin: Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. in Cancer letters 2006
VacA mediates CagA (zeige S100A8 Antikörper) phosphorylation through RPTPalpha in AZ-521 cells.
A receptor type-protein tyrosine phosphatase alpha-Src (zeige SRC Antikörper) family kinase-Rap1 (zeige RABGEF1 Antikörper) pathway was identified as responsible for recruiting myosin IIB (zeige MYH10 Antikörper) to the zonula adherens in epithelial cells and supporting contractile tension.
no evidence was seen for the association of rare, missense mutations in the PTPRA gene with schizophrenia or autism spectrum disorders
Data indicate that scaffold protein (zeige HOMER1 Antikörper) RACK1 (zeige GNB2L1 Antikörper) plays a role in IGF-1 (zeige IGF1 Antikörper)-mediated protein-tyrosine phosphatase alpha (PTPalpha) tyrosine phosphorylation in MCF-7 Cells.
recruited to epithelial adherens junctions for cadherin-dependent cell adhesion and tissue architecture formation
Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2 (zeige ERBB2 Antikörper)-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.
new role for PTPalpha in the regulation of motility of mammary epithelial cells in response to ErbB2 (zeige ERBB2 Antikörper) activation.
results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR (zeige EGFR Antikörper)) signaling with Src (zeige SRC Antikörper) activation and may provide a novel therapeutic target for treatment of breast cancer.
A single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region was found to be associated with elevated fasting glucose level.
The extracellular proteolytic processing is a novel mechanism for PTPalpha regulation.
RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis.
Ptpra coordinates the regulation of the Fyn (zeige FYN Antikörper) signaling pathway in corpus striatum.
PTPs (zeige PTS Antikörper) alpha and epsilon play distinct roles in osteoclasts.
PTP (zeige SLC25A3 Antikörper)-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta (zeige TGFB1 Antikörper).
The focal adhesion targeting domain of FAK (zeige PTK2 Antikörper) interacts with protein-tyrosine phosphatase-alpha to restrict IL1 (zeige IL1A Antikörper)-induced Ca2 (zeige CA2 Antikörper)+ release, ERK (zeige EPHB2 Antikörper) activation, and MMP-9 (zeige MMP9 Antikörper) expression.
PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord.
Findings indicate Grb2 (zeige GRB2 Antikörper) as a new FAK (zeige PTK2 Antikörper) activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration.
Inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTPalpha.
study described a molecular complex of PTPalpha-BCAR3 (zeige BCAR3 Antikörper)-Cas (zeige CTNND1 Antikörper)-Src (zeige SRC Antikörper); this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas (zeige CTNND1 Antikörper) localization to focal adhesions and Cas (zeige CTNND1 Antikörper) downstream signaling to promote cell migration
ptpra protein, zebrafish, signaling is essential for convergence and extension cell movements during gastrulation.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
protein tyrosine phosphatase, receptor type, A
, receptor-type tyrosine-protein phosphatase alpha-like
, Leukocyte common antigen-related peptide (protein tyrosine phosphate)
, PTPLCA-related phosphatase
, protein tyrosine phosphatase, receptor type, alpha polypeptide
, protein-tyrosine phosphatase alpha
, receptor-type tyrosine-protein phosphatase alpha
, tyrosine phosphatase alpha
, LCA-related phosphatase
, protein tyrosine phosphatase alpha
, protein tyrosine phosphatase receptor type alpha
, protein-tyrosine-phosphatase alpha