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PTPRA Antikörper (N-Term)

PTPRA Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB0549 unconjugated
Produktnummer ABIN392834
  • Target Alle PTPRA Antikörper anzeigen
    PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))
    Bindungsspezifität
    • 25
    • 20
    • 15
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 89-120, N-Term
    Reaktivität
    • 78
    • 46
    • 40
    • 15
    • 14
    • 13
    • 13
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 94
    Kaninchen
    Klonalität
    • 94
    Polyklonal
    Konjugat
    • 30
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser PTPRA Antikörper ist unkonjugiert
    Applikation
    • 67
    • 39
    • 39
    • 25
    • 12
    • 9
    • 8
    • 2
    Western Blotting (WB)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PTP alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-120 amino acids from the N-terminal region of human PTP alpha.
    Klon
    RB0549
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PTPRA Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))
    Andere Bezeichnung
    PTP alpha (PTPRA Produkte)
    Synonyme
    PTPRA antikoerper, heptp antikoerper, hlpr antikoerper, hptpa antikoerper, hptpalpha antikoerper, lrp antikoerper, ptpa antikoerper, ptprl2 antikoerper, r-ptp-alpha antikoerper, rptpa antikoerper, HEPTP antikoerper, HLPR antikoerper, HPTPA antikoerper, HPTPalpha antikoerper, LRP antikoerper, PTPA antikoerper, PTPRL2 antikoerper, R-PTP-alpha antikoerper, RPTPA antikoerper, Ptpa antikoerper, Ptpalpha antikoerper, Rptpalpha antikoerper, Rptra antikoerper, Rptralpha antikoerper, RPTP[a] antikoerper, zf-RPTP[a] antikoerper, ptpa-a antikoerper, protein tyrosine phosphatase, receptor type A antikoerper, protein tyrosine phosphatase, receptor type, A antikoerper, protein tyrosine phosphatase, receptor type A S homeolog antikoerper, PTPRA antikoerper, ptpra antikoerper, Ptpra antikoerper, ptpra.S antikoerper
    Hintergrund
    Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
    Molekulargewicht
    90719
    Gen-ID
    5786
    NCBI Accession
    NP_002827, NP_543030, NP_543031
    UniProt
    P18433
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