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PRMT1 encodes a member of the protein arginine N-methyltransferase (PRMT) family. Zusätzlich bieten wir Ihnen PRMT1 Proteine (29) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PRMT1 Primary Antibody für IHC (p), IP - ABIN151674
Fisk, Zurita-Lopez, Sayegh, Tomasello, Clarke, Read: TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei. in Eukaryotic cell 2010
PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
High PRMT1 expression is associated with multidrug resistance in breast cancer.
IFNgamma induced PPAR gamma coactivator-1 alpha (PGC-1alpha (zeige PPARGC1A Antikörper)) positively regulated RIG-I (zeige DDX58 Antikörper); with PRMT-1 and G9a (zeige EHMT2 Antikörper) affecting PGC-1alpha (zeige PPARGC1A Antikörper) in a counter-regulatory manner.
PRMT1 inhibition prevents gastric cancer progression by downregulating eIF4E (zeige EIF4E Antikörper) and targeting type II PRMT5 (zeige PRMT5 Antikörper).
RALY (zeige RALY Antikörper) promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells
the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 (zeige DDX1 Antikörper) and C14orf166 (zeige C14orf166 Antikörper) are required for PRMT1 expression in colorectal cancer cell lines
Maintenance of the progenitors thus requires cooperation by PRMT1 and CSNK1a1 (zeige CSNK1A1 Antikörper) to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3 (zeige GRHL3 Antikörper)
PRMT1 methylates Nrf2 (zeige GABPA Antikörper) protein at a single residue of arginine 437, both in vitro and in vivo. This leads to a moderate increase of its DNA-binding activity and transactivation, which subsequently protects cells against the tBHP-induced glutathione depletion and cell death.
Our data suggest that miR (zeige MLXIP Antikörper)-19a and PRMT1 might be novel indicators of asthma and present new disease-specific therapeutic targets to reduce airway wall remodeling and inflammation in asthmatic patients
The PRMT1 active site residues, Met48 and His293, have been determined to play a key role in dictating product specificity, as: (1) the single mutation of Met48 to Phe enabled PRMT1 to generate MMA, ADMA, and a limited amount of SDMA; (2) the single mutation of His293 to Ser (zeige SIGLEC1 Antikörper) formed the expected MMA and ADMA products only; (3) the double mutant H293S-M48F-PRMT1 produced SMDA as the major product with limit amount of SDMA.
prmt8 (zeige PRMT8 Antikörper) may play important roles non-overlapping with prmt1 in embryonic and neural development depending on its specific N-terminus.
prmt1 gene is actively and ubiquitously expressed at both RNA and protein levels at the early developmental stages of zebrafish.
PRMT1 functions transiently as a coactivator in thyroid hormone (zeige PTH Antikörper) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
Results suggest that part of the type I arginine methyltransferases in brains, mainly PRMT1, are sequestered in an inactive form as they associated with membranes or large subcellular complexes.
Collectively, this study firstly demonstrated that PRMT1 exert podocyte-injury effects in mouse glomerulus through Ang (zeige ANG Antikörper) /ERK (zeige EPHB2 Antikörper) pathway, which reveals a potential therapeutic target for DN.
Low Prmt1 expression is associated with osteosarcoma.
Collectively, the authors propose that Prmt1-dependent facilitation of KCNQ (zeige KCNQ1 Antikörper)-phosphatidylinositol-4,5-bisphosphate interaction underlies the positive regulation of KCNQ (zeige KCNQ1 Antikörper) activity by arginine methylation, which may serve as a key target for prevention of neuronal hyperexcitability and seizures.
Results identify a key molecular mechanism by which the BTG2 (zeige BTG2 Antikörper)-PRMT1 module regulates pre-B cell differentiation and inhibits pre-B cell leukemogenesis.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc (zeige MYC Antikörper) binding to acetyltransferase p300 (zeige NOTCH1 Antikörper) in myeloid cells; Prmt1 inhibition decreases p300 (zeige NOTCH1 Antikörper) recruitment to c-Myc (zeige MYC Antikörper) target promoters and increased Hdac1 (zeige HDAC1 Antikörper) recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc (zeige MYC Antikörper) = Proto-Oncogene (zeige RAB1A Antikörper) Proteins c-myc (zeige MYC Antikörper); Hdac1 (zeige HDAC1 Antikörper) = histone deacetylase 1 (zeige HDAC1 Antikörper)]
PRMT1-dependent regulation of macrophage PPARgamma (zeige PPARG Antikörper) expression contributes to the infection susceptibility in PRMT1 knock-out mice
These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1 (zeige EYA1 Antikörper)/Six1 (zeige SIX1 Antikörper)/MyoD (zeige MYOD1 Antikörper) axis.
PRMT1 is necessary for lymphocyte functions in vivo.
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
protein arginine N-methyltransferase 1
, protein arginine methyltransferase 1
, protein arginine N-methyltransferase
, HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
, heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
, histone-arginine N-methyltransferase PRMT1
, interferon receptor 1-bound protein 4
, HMT1 hnRNP methyltransferase-like 2
, histone-arginine N-methyltransferase PRMT1-A
, protein arginine N-methyltransferase 1-A
, heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
, arginine N-methyltransferase 1