anti-Protein AF-10 (MLLT10) Antikörper

MLLT10 encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human MLLT10 MLLT10 8028 P55197
Anti-Maus MLLT10 MLLT10 17354 O54826
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Top anti-MLLT10 Antikörper auf antikoerper-online.de

Showing 10 out of 132 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from COLO205/Jurkat cells, using AF10 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Ratte Ziege Unkonjugiert ELISA, WB Western Blot: AF10 Antibody [NBP1-49867] - Western blot analysis of AF10 in Rat Testis lysate (35ug protein in RIPA buffer) using NBP1-49867 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Ratte Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-MLLT10 Pab (ABIN390125) in Jurkat cell line lysate. MLLT10(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Rind (Kuh) Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$462.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Huhn Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded SCC xenograft, using AF10, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE AF10 antibody antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p) Human Testis (formalin-fixed, paraffin-embedded) stained with MLLT10 antibody ABIN214674 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IF, WB Western blot analysis of MLLT10 (ABIN1882102) in K562 cell line lysates (35 µg/lane). MLLT10 (arrow) was detected using the purified Pab. (2 µg/ml) Western blot analysis of MLLT10 (ABIN1882102) in K562 cell line lysates (35 µg/lane). MLLT10 (arrow) was detected using the purified Pab. (2 µg/ml) 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details

Am meisten referenzierte anti-MLLT10 Antikörper

  1. Human Polyclonal MLLT10 Primary Antibody für IF, WB - ABIN1882102 : Cai, Gao, Sheng, Miao, Cui, Wang, Zong, Koide: Characterization and potential function of a novel testis-specific nucleoporin BS-63. in Molecular reproduction and development 2002 (PubMed)
    Show all 6 Pubmed References

  2. Rat (Rattus) Polyclonal MLLT10 Primary Antibody für ELISA, WB - ABIN4278553 : Lin, Kakadia, Chen, Li, Deshpande, Buske, Zhang, Zhang, Xu, Bohlander: Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. in Blood 2009 (PubMed)

Weitere Antikörper gegen MLLT10 Interaktionspartner

Human Protein AF-10 (MLLT10) Interaktionspartner

  1. In a retroviral transduction/transplantation mouse model, mice transplanted with MLL (zeige MLL Antikörper)/AF10(OM-LZ) cells harboring PTPN11 (zeige PTPN11 Antikörper)(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11 (zeige PTPN11 Antikörper)(G503A) -induced monocytic leukemia (zeige KAT6B Antikörper) in a shorter latency. Adding PTPN11 (zeige PTPN11 Antikörper)(G503A) to MLL (zeige MLL Antikörper)/AF10 affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.

  2. Our results provide evidence for new loci influencing abdominal visceral (BBS9 (zeige BBS9 Antikörper), ADCY8 (zeige ADCY8 Antikörper), KCNK9 (zeige KCNK9 Antikörper)) and subcutaneous (MLLT10/DNAJC1 (zeige DNAJC1 Antikörper)/EBLN1 (zeige EBLN2 Antikörper)) fat, and confirmed a locus (THNSL2 (zeige THNSL2 Antikörper)) previously reported to be associated with abdominal fat in women

  3. The PZP (zeige PZP Antikörper) domain of AF10 senses unmodified H3K27 to regulate DOT1L (zeige DOT1L Antikörper)-mediated methylation of H3K79.

  4. we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma).

  5. Results provide evidence that transformation driven by MLL (zeige MLL Antikörper) fusions as well as the recurrent AML (zeige RUNX1 Antikörper)-associated NUP98 (zeige NUP98 Antikörper)-NSD1 (zeige NSD1 Antikörper) fusion oncogene (zeige RAB1A Antikörper) is critically dependent on the ability of AF10 to stimulate DOT1L (zeige DOT1L Antikörper) activity.

  6. detection of PICALM (zeige PICALM Antikörper)-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy

  7. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1 (zeige HNRNPH1 Antikörper)/5q35 and DDX3X (zeige DDX3X Antikörper)/Xp11.3 as new MLLT10 fusion partners.

  8. results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood

  9. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  10. a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified.

Mouse (Murine) Protein AF-10 (MLLT10) Interaktionspartner

  1. Results provide evidence that transformation driven by MLL (zeige MLL Antikörper) fusions as well as the recurrent AML (zeige RUNX1 Antikörper)-associated NUP98 (zeige NUP98 Antikörper)-NSD1 (zeige NSD1 Antikörper) fusion oncogene (zeige RAB1A Antikörper) is critically dependent on the ability of AF10 to stimulate DOT1L (zeige DOT1L Antikörper) activity.

  2. During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.

  3. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  4. further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains

  5. conclude that Mllt10/Af10-Dot1l (zeige DOT1L Antikörper) are essential, largely dedicated activators of Wnt (zeige WNT2 Antikörper)-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis

MLLT10 Antigen-Profil

Protein Überblick

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-Protein AF-10 (MLLT10) Antikörper

  • MLLT10, histone lysine methyltransferase DOT1L cofactor (MLLT10) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 (Mllt10) Antikörper
  • Af10 Antikörper
  • B130021D15Rik Antikörper
  • D630001B22Rik Antikörper
  • mKIAA4140 Antikörper

Bezeichner auf Proteinebene für anti-Protein AF-10 (MLLT10) Antikörper

ALL1-fused gene from chromosome 10 protein , protein AF-10 , type I AF10 protein , type III AF10 protein , type IV AF10 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog

GENE ID SPEZIES
8028 Homo sapiens
17354 Mus musculus
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