anti-Protein AF-10 (MLLT10) Antikörper

MLLT10 encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Zusätzlich bieten wir Ihnen MLLT10 Proteine (3) und MLLT10 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MLLT10 8028 P55197
MLLT10 17354 O54826
MLLT10    
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Top anti-MLLT10 Antikörper auf antikoerper-online.de

Showing 10 out of 125 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from COLO205/Jurkat cells, using AF10 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
€267.70
Details
Ratte Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
€380.39
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Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-MLLT10 Pab (ABIN390125) in Jurkat cell line lysate. MLLT10(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
€340.71
Details
Rind (Kuh) Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
€408.85
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
€345.58
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Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
€158.02
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Huhn Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
€540.27
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from COLO205 cells using AF10 antibody. ABIN6274293 staining COLO205 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
€345.81
Details
Human Kaninchen Unkonjugiert IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded SCC xenograft, using AF10, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE AF10 antibody antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
€412.55
Details
Ratte Ziege Unkonjugiert ELISA, WB Western Blot: AF10 Antibody [NBP1-49867] - Western blot analysis of AF10 in Rat Testis lysate (35ug protein in RIPA buffer) using NBP1-49867 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
€432.50
Details

Am meisten referenzierte anti-MLLT10 Antikörper

  1. Human Polyclonal MLLT10 Primary Antibody für IF, WB - ABIN1882102 : Cai, Gao, Sheng, Miao, Cui, Wang, Zong, Koide: Characterization and potential function of a novel testis-specific nucleoporin BS-63. in Molecular reproduction and development 2002 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal MLLT10 Primary Antibody für IHC (p), ELISA - ABIN545691 : Nakamura, Mori, Tada, Krajewski, Rozovskaia, Wassell, Dubois, Mazo, Croce, Canaani: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. in Molecular cell 2002 (PubMed)
    Show all 3 Pubmed References

  3. Rat (Rattus) Polyclonal MLLT10 Primary Antibody für ELISA, WB - ABIN4278553 : Lin, Kakadia, Chen, Li, Deshpande, Buske, Zhang, Zhang, Xu, Bohlander: Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. in Blood 2009 (PubMed)

Weitere Antikörper gegen MLLT10 Interaktionspartner

Human Protein AF-10 (MLLT10) Interaktionspartner

  1. In vitro, the overexpression of MLLT10 promoted colorectal cancer (CRC) cell migration and invasion, while after MLLT10 was knocked down, the opposite results were observed. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT.

  2. In a retroviral transduction/transplantation mouse model, mice transplanted with MLL/AF10(OM-LZ) cells harboring PTPN11(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11(G503A) -induced monocytic leukemia in a shorter latency. Adding PTPN11(G503A) to MLL/AF10 affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.

  3. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women

  4. The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79.

  5. we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma).

  6. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.

  7. detection of PICALM-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy

  8. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners.

  9. results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood

  10. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  11. a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified.

  12. FISH analysis in infant AML-M5 showed a complex rearrangement between chromosomes 10 and 11, disrupting the MLL gene, a paracentric inversion of the 11q13-q23 fragment translocated to 10p12. AF10 was the fusion partner gene of MLL in this rearrangement.

  13. ALL1 is involved in remodeling, acetylating, deacetylating, and methylating nucleosomes and/or free histones

  14. data reveal new properties for the leucine zipper domain and thus might provide new clues to understanding the mechanisms by which AF10 fusion proteins in which the PHD domain is lost might trigger leukemias in humans

  15. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF10.

  16. Data show that the nuclear isoform of FLRG lacks an intrinsic transactivation domain, but enhances AF10-mediated transcription, probably through promoting the homo-oligomerization of AF10, thus facilitating the recruitment of co-activators.

  17. CALM(PICALM)/AF10 fusion protein might interfere with normal Ikaros (IKZF1)function, and thereby block lymphoid differentiation in CALM/AF10 positive leukemias.

  18. the CALM-AF10 fusion protein can also greatly reduce global H3K79 methylation in both human and murine leukemic cells by disrupting the AF10-mediated association of hDOT1L with chromatin

Mouse (Murine) Protein AF-10 (MLLT10) Interaktionspartner

  1. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT.

  2. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.

  3. During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.

  4. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  5. further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains

  6. conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis

MLLT10 Antigen-Profil

Protein Überblick

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-Protein AF-10 (MLLT10) Antikörper

  • MLLT10, histone lysine methyltransferase DOT1L cofactor (MLLT10) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 (Mllt10) Antikörper
  • Af10 Antikörper
  • B130021D15Rik Antikörper
  • D630001B22Rik Antikörper
  • mKIAA4140 Antikörper

Bezeichner auf Proteinebene für anti-Protein AF-10 (MLLT10) Antikörper

ALL1-fused gene from chromosome 10 protein , protein AF-10 , type I AF10 protein , type III AF10 protein , type IV AF10 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog

GENE ID SPEZIES
8028 Homo sapiens
17354 Mus musculus
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