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MLLT10 encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias.
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Human Polyclonal MLLT10 Primary Antibody für IF, WB - ABIN1882102
Cai, Gao, Sheng, Miao, Cui, Wang, Zong, Koide: Characterization and potential function of a novel testis-specific nucleoporin BS-63. in Molecular reproduction and development 2002
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Rat (Rattus) Polyclonal MLLT10 Primary Antibody für ELISA, WB - ABIN4278553
Lin, Kakadia, Chen, Li, Deshpande, Buske, Zhang, Zhang, Xu, Bohlander: Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. in Blood 2009
In a retroviral transduction/transplantation mouse model, mice transplanted with MLL (zeige MLL Antikörper)/AF10(OM-LZ) cells harboring PTPN11 (zeige PTPN11 Antikörper)(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11 (zeige PTPN11 Antikörper)(G503A) -induced monocytic leukemia (zeige KAT6B Antikörper) in a shorter latency. Adding PTPN11 (zeige PTPN11 Antikörper)(G503A) to MLL (zeige MLL Antikörper)/AF10 affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.
Our results provide evidence for new loci influencing abdominal visceral (BBS9 (zeige BBS9 Antikörper), ADCY8 (zeige ADCY8 Antikörper), KCNK9 (zeige KCNK9 Antikörper)) and subcutaneous (MLLT10/DNAJC1 (zeige DNAJC1 Antikörper)/EBLN1 (zeige EBLN2 Antikörper)) fat, and confirmed a locus (THNSL2 (zeige THNSL2 Antikörper)) previously reported to be associated with abdominal fat in women
The PZP (zeige PZP Antikörper) domain of AF10 senses unmodified H3K27 to regulate DOT1L (zeige DOT1L Antikörper)-mediated methylation of H3K79.
we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma).
Results provide evidence that transformation driven by MLL (zeige MLL Antikörper) fusions as well as the recurrent AML (zeige RUNX1 Antikörper)-associated NUP98 (zeige NUP98 Antikörper)-NSD1 (zeige NSD1 Antikörper) fusion oncogene (zeige RAB1A Antikörper) is critically dependent on the ability of AF10 to stimulate DOT1L (zeige DOT1L Antikörper) activity.
detection of PICALM (zeige PICALM Antikörper)-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy
In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1 (zeige HNRNPH1 Antikörper)/5q35 and DDX3X (zeige DDX3X Antikörper)/Xp11.3 as new MLLT10 fusion partners.
results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood
In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin
a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified.
During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.
further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains
conclude that Mllt10/Af10-Dot1l (zeige DOT1L Antikörper) are essential, largely dedicated activators of Wnt (zeige WNT2 Antikörper)-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.
ALL1-fused gene from chromosome 10 protein
, protein AF-10
, type I AF10 protein
, type III AF10 protein
, type IV AF10 protein
, myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog